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Synthesis 1986; 1986(1): 45-46
DOI: 10.1055/s-1986-31471
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An Improved Procedure for the Protection of 2′-Deoxyguanosine

Fritz Benseler* , Larry W. Mclaughlin
  • *Abteilung Chemie, Max-Planck-Institut für experimentelle Medizin, Hermann-Rein-Straße 3, D-3400 Göttingen, Federal Republic of Germany
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Publication Date:
20 August 2002 (online)

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N 2-Phenylacetyl-2′-deoxyguanosine can be prepared in high yield and exceptional purity by pretreating phenylacetyl chloride with 1-hydroxybenzotriazole and adding the thus formed adduct to the tris[trimethylsilyl] ether derivative of 2′-deoxyguanosine. Subsequently, the crystalline product can be treated with 9-chloro-9-phenylxanthene which results in a crystalline material suitable for use in oligodeoxyribonucleotide synthesis procedures.