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Synthesis 1985; 1985(10): 926-928
DOI: 10.1055/s-1985-31385
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A Convenient Preparation of S-Adenosylhomocysteine and its Analogues

Paweł Serafinowski*
  • *Department of Biochemical Pharmacology, Section of Drug Development, Institute of Cancer Research, Sutton, Surrey, SM2 5PX, U.K.
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Publikationsdatum:
27. September 2002 (online)

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N,N-Bis[trifluoroacetyl]-L-homocystine dimethyl ester (1) was condensed with adenosine (2a), 3-deazaadenosine (2b), and 7-deazaadenosine (2c) in the presence of tri-n-butylphosphine in pyridine or dimethylformamide to give the N-trifluoroacetyl-Sadenosyl-homocysteine derivatives 3a, 3b and 3c with aqueous barium hydroxide afforded S-adenosylhomocysteine (4a), S-3-deazaadenosylhomocysteine (4b), and S-7-deazaadenosylhomocysteine (4c) in good yields.