Pharmacopsychiatry 2025; 58(03): 147-148
DOI: 10.1055/s-0045-1807310
Abstracts | AGNP/DGBP
Poster

A genome-wide association study of brain function across multiple cognitive domains

L Waller
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
A-L Bröcker
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
N Elbersgerd
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
F Jaeck
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
R Lipka
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
L Mograby
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
M Neidhart
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
R Puzicha
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
F Rahimova
2   Adaptive Systems Lab, Department of Computer Science, Humboldt-Universität zu Berlin, Berlin, Germany
,
P Reinhardt
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
Z Reppmann
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
N Schäfer
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
E Serin
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
N Vaidya
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
B Vogel
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
S Wellan
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
J Winterer
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
D Göller
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
G-I Henze
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
F Pizzagalli
3   Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy
4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
,
C D'Agostino
3   Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy
,
Z Liao
5   Departments of Psychiatry and Neuroscience and CHU Sainte Justine, University of Montreal, Montreal, QC, H3T 1C5, Canada
,
T Paus
6   Departments of Psychiatry and Neuroscience and Centre Hospitalier Universitaire Sainte Justine, University of Montreal, Montreal, QC, H3T 1C5, Canada
,
L Nyberg
7   Department of Integrative Medical Biology (IMB), Faculty of Medicine, Umeå University, Umeå, Sweden
8   Umeå Centre for Functional Brain Imaging (UFBI), Faculty of Medicine, Umeå University, Umeå, Sweden
,
M Andersson
7   Department of Integrative Medical Biology (IMB), Faculty of Medicine, Umeå University, Umeå, Sweden
8   Umeå Centre for Functional Brain Imaging (UFBI), Faculty of Medicine, Umeå University, Umeå, Sweden
,
M Hermesdorf
9   Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
,
K Berger
9   Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany
,
U Dannlowski
10   Institute for Translational Psychiatry, University of Münster, Münster, Germany
,
T Kircher
11   Department of Psychiatry, University of Marburg, Germany
,
D Grotegerd
10   Institute for Translational Psychiatry, University of Münster, Münster, Germany
10   Institute for Translational Psychiatry, University of Münster, Münster, Germany
,
A Forstner
12   Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
,
F David
12   Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany
,
P Mitchell
13   Discipline of Psychiatry and Mental Health, School of Medicine and Health, University of New South Wales, Australia
,
G Roberts
13   Discipline of Psychiatry and Mental Health, School of Medicine and Health, University of New South Wales, Australia
,
DE J Linden
14   School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
15   Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK
,
K Singh
15   Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK
,
T M Lancaster
15   Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK
16   UK Dementia Research Institute, School of Medicine, Cardiff University, UK
17   Department of Psychology, University of Bath, Bath, UK
,
X Caseras
18   Division of Psychological Medicine and Clinical Neurosciences, Cardiff, UK
,
A Knodt
19   Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
,
A Hariri
19   Department of Psychology and Neuroscience, Duke University, Durham, NC, USA
,
MÁ García-León
20   Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain
21   FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain
,
P Fuentes-Claramonte
20   Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain
21   FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain
,
E Pomarol-Clotet
20   Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain
21   FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain
,
A Holmes
22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia
,
S Chopra
23   Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia; Orygen, Parkville, Australia
,
T T Rana
22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia
,
A Fornito
22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia
,
J Tiego
22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia
,
M Bellgrove
22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia
,
O Gruber
24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany
,
J Treutlein
24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany
,
K E Einenkel
24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany
,
R Peretzke
24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany
,
M Fischer
24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany
,
B J Harrison
25   Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia
,
A J Jamieson
25   Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia
,
C G Davey
25   Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia
,
Y Quidé
26   School of Psychology, University of New South Wales (UNSW), Sydney, NSW, Australia
27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia
,
O J Watkeys
28   Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales (UNSW), Sydney, NSW, Australia
27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia
,
M J Green
28   Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales (UNSW), Sydney, NSW, Australia
27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia
,
P M Aggensteiner
29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany
,
M Monninger
29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany
,
N Holz
29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany
,
T Banaschewski
29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany
,
P Sämann
29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany
,
LK M Han
30   Orygen, Parkville, VIC, Australia
31   Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia
,
BWJ H Penninx
32   Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands
,
Y Milaneschi
32   Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands
,
L T Strike
33   QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
33   QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
,
A Bertolino
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
G Pergola
35   Lieber Institute for Brain Development, Baltimore, MD, USA
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
L Fazio
36   Department of Medicine and Surgery, LUM University, Casamassima-Bari, Italy
,
G Stolfa
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
R Passiatore
35   Lieber Institute for Brain Development, Baltimore, MD, USA
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
A Lella
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
N Sambuco
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
L Sportelli
35   Lieber Institute for Brain Development, Baltimore, MD, USA
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
G Kikidis
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
A Rampino
34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy
,
R Tatham
37   Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK
,
L Romaniuk
37   Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK
,
H C Whalley
37   Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK
,
HR P Park
27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia
26   School of Psychology, University of New South Wales (UNSW), Sydney, NSW, Australia
,
J M Gatt
27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia
26   School of Psychology, University of New South Wales (UNSW), Sydney, NSW, Australia
,
P R Schofield
38   School of Biomedical Sciences, University of New South Wales (UNSW), Sydney, NSW, Australia
27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia
,
L M Williams
39   Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, California, USA
,
F Hoffstaedter
40   Institute of Neuroscience and Medicine (INM-7), Forschungszentrum Jülich, Jülich, Germany
,
A H Zhu
4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
,
N Jahanshad
4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
,
T E Nichols
41   Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
42   Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
,
P M Thompson
4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
,
S E Medland
33   QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
,
I M Veer
43   Department of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands
,
S Erk
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
,
H Walter
1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
› Author Affiliations
 

Task-based fMRI is widely used to study the neurobiological basis of behavior, cognition, and emotion. Previous studies disagree on whether statistics derived from task-based fMRI are heritable – estimates range from approximately five percent to more than forty percent. Here we present the largest and most diverse genome-wide association study of task-based fMRI to date that uses a single, harmonized data analysis pipeline across all contributing sites. This abstract reports the SNP-based heritability results obtained from the current sample.

We invited researchers with access to relevant data to contribute through the ENIGMA consortium and public postings on social media. We chose three tasks that have been widely used for inclusion in the study. These are emotional faces, working memory, and reward tasks.

SNP-based analyses of seven datasets show moderate heritability across a wide range of brain regions for emotional faces and reward tasks. The amygdala is known to have a large effect size in the emotional faces task. However, we find greater heritability in cortical regions not commonly associated with the task. For reward, we found the maximum heritability in the striatum, which is consistent with brain maps found by imaging-only studies. We did not find significant heritability for working memory, likely due to a lack of statistical power. At time of writing, not all sites planned for inclusion in the meta-analysis have completed data analysis. We expect to increase statistical power by including these datasets.

Our results are consistent with previous findings of SNP-based heritability for the amygdala in the emotional faces task. This demonstrates the feasibility of genome-wide association studies for investigating individual differences in task-based fMRI. The results presented here will inform secondary analyses including genetic correlations and annotation. These may provide important insights into the relation of genes, molecules, cells, and circuits to psychological domains.



Publication History

Article published online:
30 April 2025

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