Pharmacopsychiatry 2025; 58(03): 147-148
DOI: 10.1055/s-0045-1807310
Abstracts | AGNP/DGBP
Poster

A genome-wide association study of brain function across multiple cognitive domains

Authors

  • L Waller

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • A-L Bröcker

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • N Elbersgerd

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • F Jaeck

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • R Lipka

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • L Mograby

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • M Neidhart

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • R Puzicha

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • F Rahimova

    2   Adaptive Systems Lab, Department of Computer Science, Humboldt-Universität zu Berlin, Berlin, Germany

  • P Reinhardt

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • Z Reppmann

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • N Schäfer

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • E Serin

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • N Vaidya

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • B Vogel

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • S Wellan

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • J Winterer

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • D Göller

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • G-I Henze

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • F Pizzagalli

    3   Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy
    4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA

  • C D'Agostino

    3   Department of Neuroscience “Rita Levi Montalcini”, University of Turin, Turin, Italy

  • Z Liao

    5   Departments of Psychiatry and Neuroscience and CHU Sainte Justine, University of Montreal, Montreal, QC, H3T 1C5, Canada

  • T Paus

    6   Departments of Psychiatry and Neuroscience and Centre Hospitalier Universitaire Sainte Justine, University of Montreal, Montreal, QC, H3T 1C5, Canada

  • L Nyberg

    7   Department of Integrative Medical Biology (IMB), Faculty of Medicine, Umeå University, Umeå, Sweden
    8   Umeå Centre for Functional Brain Imaging (UFBI), Faculty of Medicine, Umeå University, Umeå, Sweden

  • M Andersson

    7   Department of Integrative Medical Biology (IMB), Faculty of Medicine, Umeå University, Umeå, Sweden
    8   Umeå Centre for Functional Brain Imaging (UFBI), Faculty of Medicine, Umeå University, Umeå, Sweden

  • M Hermesdorf

    9   Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany

  • K Berger

    9   Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany

  • U Dannlowski

    10   Institute for Translational Psychiatry, University of Münster, Münster, Germany

  • T Kircher

    11   Department of Psychiatry, University of Marburg, Germany

  • D Grotegerd

    10   Institute for Translational Psychiatry, University of Münster, Münster, Germany
    10   Institute for Translational Psychiatry, University of Münster, Münster, Germany

  • A Forstner

    12   Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany

  • F David

    12   Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany

  • P Mitchell

    13   Discipline of Psychiatry and Mental Health, School of Medicine and Health, University of New South Wales, Australia

  • G Roberts

    13   Discipline of Psychiatry and Mental Health, School of Medicine and Health, University of New South Wales, Australia

  • DE J Linden

    14   School for Mental Health and Neuroscience, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands
    15   Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK

  • K Singh

    15   Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK

  • T M Lancaster

    15   Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, UK
    16   UK Dementia Research Institute, School of Medicine, Cardiff University, UK
    17   Department of Psychology, University of Bath, Bath, UK

  • X Caseras

    18   Division of Psychological Medicine and Clinical Neurosciences, Cardiff, UK

  • A Knodt

    19   Department of Psychology and Neuroscience, Duke University, Durham, NC, USA

  • A Hariri

    19   Department of Psychology and Neuroscience, Duke University, Durham, NC, USA

  • MÁ García-León

    20   Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain
    21   FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain

  • P Fuentes-Claramonte

    20   Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain
    21   FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain

  • E Pomarol-Clotet

    20   Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spain
    21   FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Catalonia, Spain

  • A Holmes

    22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia

  • S Chopra

    23   Centre for Youth Mental Health, The University of Melbourne, Melbourne, Australia; Orygen, Parkville, Australia

  • T T Rana

    22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia

  • A Fornito

    22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia

  • J Tiego

    22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia

  • M Bellgrove

    22   School of Psychological Sciences, Turner Institite for Brain and Mental Health, and Monash Biomedical Imaging, Monash University, Melbourne, Australia

  • O Gruber

    24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany

  • J Treutlein

    24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany

  • K E Einenkel

    24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany

  • R Peretzke

    24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany

  • M Fischer

    24   Section for Experimental Psychopathology and Neuroimaging, Department of General Psychiatry, Heidelberg University, Heidelberg, Germany

  • B J Harrison

    25   Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia

  • A J Jamieson

    25   Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia

  • C G Davey

    25   Department of Psychiatry, The University of Melbourne, Melbourne, VIC, Australia

  • Y Quidé

    26   School of Psychology, University of New South Wales (UNSW), Sydney, NSW, Australia
    27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia

  • O J Watkeys

    28   Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales (UNSW), Sydney, NSW, Australia
    27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia

  • M J Green

    28   Discipline of Psychiatry and Mental Health, School of Clinical Medicine, University of New South Wales (UNSW), Sydney, NSW, Australia
    27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia

  • P M Aggensteiner

    29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany

  • M Monninger

    29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany

  • N Holz

    29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany

  • T Banaschewski

    29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany

  • P Sämann

    29   Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim and Heidelberg University, Mannheim, Germany

  • LK M Han

    30   Orygen, Parkville, VIC, Australia
    31   Centre for Youth Mental Health, The University of Melbourne, Parkville, VIC, Australia

  • BWJ H Penninx

    32   Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands

  • Y Milaneschi

    32   Amsterdam UMC location Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands

  • L T Strike

    33   QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia
    33   QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

  • A Bertolino

    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • G Pergola

    35   Lieber Institute for Brain Development, Baltimore, MD, USA
    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • L Fazio

    36   Department of Medicine and Surgery, LUM University, Casamassima-Bari, Italy

  • G Stolfa

    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • R Passiatore

    35   Lieber Institute for Brain Development, Baltimore, MD, USA
    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • A Lella

    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • N Sambuco

    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • L Sportelli

    35   Lieber Institute for Brain Development, Baltimore, MD, USA
    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • G Kikidis

    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • A Rampino

    34   Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy

  • R Tatham

    37   Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK

  • L Romaniuk

    37   Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK

  • H C Whalley

    37   Division of Psychiatry, Centre for Clinical Brain Sciences, University of Edinburgh, UK

  • HR P Park

    27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia
    26   School of Psychology, University of New South Wales (UNSW), Sydney, NSW, Australia

  • J M Gatt

    27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia
    26   School of Psychology, University of New South Wales (UNSW), Sydney, NSW, Australia

  • P R Schofield

    38   School of Biomedical Sciences, University of New South Wales (UNSW), Sydney, NSW, Australia
    27   Neuroscience Research Australia (NeuRA), Randwick, NSW, Australia

  • L M Williams

    39   Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, Stanford, California, USA

  • F Hoffstaedter

    40   Institute of Neuroscience and Medicine (INM-7), Forschungszentrum Jülich, Jülich, Germany

  • A H Zhu

    4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA

  • N Jahanshad

    4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA
    4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA

  • T E Nichols

    41   Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
    42   Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom

  • P M Thompson

    4   Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, USA

  • S E Medland

    33   QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia

  • I M Veer

    43   Department of Developmental Psychology, University of Amsterdam, Amsterdam, The Netherlands

  • S Erk

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany

  • H Walter

    1   Charité Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Psychiatry and Neurosciences CCM, Berlin, Germany
Further Information
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Task-based fMRI is widely used to study the neurobiological basis of behavior, cognition, and emotion. Previous studies disagree on whether statistics derived from task-based fMRI are heritable – estimates range from approximately five percent to more than forty percent. Here we present the largest and most diverse genome-wide association study of task-based fMRI to date that uses a single, harmonized data analysis pipeline across all contributing sites. This abstract reports the SNP-based heritability results obtained from the current sample.

We invited researchers with access to relevant data to contribute through the ENIGMA consortium and public postings on social media. We chose three tasks that have been widely used for inclusion in the study. These are emotional faces, working memory, and reward tasks.

SNP-based analyses of seven datasets show moderate heritability across a wide range of brain regions for emotional faces and reward tasks. The amygdala is known to have a large effect size in the emotional faces task. However, we find greater heritability in cortical regions not commonly associated with the task. For reward, we found the maximum heritability in the striatum, which is consistent with brain maps found by imaging-only studies. We did not find significant heritability for working memory, likely due to a lack of statistical power. At time of writing, not all sites planned for inclusion in the meta-analysis have completed data analysis. We expect to increase statistical power by including these datasets.

Our results are consistent with previous findings of SNP-based heritability for the amygdala in the emotional faces task. This demonstrates the feasibility of genome-wide association studies for investigating individual differences in task-based fMRI. The results presented here will inform secondary analyses including genetic correlations and annotation. These may provide important insights into the relation of genes, molecules, cells, and circuits to psychological domains.



Publication History

Article published online:
30 April 2025

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