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DOI: 10.1055/s-0043-1775483
Concise Synthesis of Ethericins A and B, C10-Deoxygerfelin, and Diorcinol
This work was supported by the National Natural Science Foundation of China, Regional Project (Grant No. 22061008, 22361008).
Abstract
Naturally occurring diaryl ethers exhibit significant potential for pharmaceutical and agricultural applications owing to their diverse biological activities. Previous synthetic approaches to these bioactive molecules have predominantly focused on developing novel aryl–O–aryl bond formation methodologies. In this study, a two-phase synthetic strategy is presented, comprising a coupling phase establishing the ethereal linkage through SNAr reaction between simple aryl substrates, followed by a functionalization phase enabling precise introduction of diverse substituents through C–H activation and subsequent cross-coupling transformations. This modular approach has enabled the efficient synthesis of four natural products: ethericin A, ethericin B, C10-deoxygerfelin, and diorcinol.
Key words
diaryl ether - two-phase synthesis - ethericin A - ethericin B - C10-deoxygerfelin - diorcinolSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1775483.
- Supporting Information
Publication History
Received: 04 March 2025
Accepted after revision: 09 April 2025
Article published online:
05 May 2025
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For selected examples of Ru-catalyzed C–H activation, see: