A Portal to Highly Valuable Pyridonyl Vinyl Sulfonyl Fluorides and Aliphatic Sulfonyl Fluorides

Shi-Qi Zeng; Eman Fayad; Ola A. Abu Ali; Bing Sun; Hua-Li Qin

doi:10.1055/s-0043-1773500

Synthesis, Table of Contents

Synthesis 2025; 57(04): 835-845
DOI: 10.1055/s-0043-1773500

paper

A Portal to Highly Valuable Pyridonyl Vinyl Sulfonyl Fluorides and Aliphatic Sulfonyl Fluorides

Shi-Qi Zeng

^aSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, P. R. of China

,

Eman Fayad

^bDepartment of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia

,

Ola A. Abu Ali

^cDepartment of Chemistry, College of Science, Taif University, Taif 21944, Saudi Arabia

,

Bing Sun

^aSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, P. R. of China

,

Hua-Li Qin∗

^aSchool of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, P. R. of China

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Abstract

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Abstract

A novel and efficient method for selective Michael addition of 2-pyridones to ethenesulfonyl fluoride (ESF) and 1-bromoethene-1-sulfonyl fluoride (BESF) has been developed for constructing a class of pyridonyl aliphatic sulfonyl fluorides and pyridonyl vinyl sulfonyl fluorides in good to excellent yields. This practical method features easy operation, wide substrate scope, and mild reaction conditions.

Key words

2-pyridones - pyridonyl vinyl sulfonyl fluorides - Michael addition - pyridonyl aliphatic sulfonyl fluorides - click chemistry

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References

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