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Synlett 2024; 35(18): 2113-2116
DOI: 10.1055/s-0043-1763749
DOI: 10.1055/s-0043-1763749
letter
Expedient Synthesis of gem-CF2-2H-Thiophenes from Enaminothiones
Authors
The authors gratefully acknowledge funding from the National Natural Science Foundation of China (21971112 and 22361010).
Abstract
An expedient and easy-to-handle synthetic platform has been established for the constructing of 2H-thiophenes carrying fluorine atoms through [4+1] cyclization of enaminothiones with fluorinated carbene precursors. This simple reaction system is well compatible with a wide range of substrates under completely metal-free conditions. The resulting 2H-thiophenes can undergo further late-stage modifications to yield a wide range of fluorine-substituted heterocycles.
Key words
carbene chemistry - [4+1] cyclization - enaminothiones - fluorinated 2H-thiophenes - difluorocarbeneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0043-1763749.
- Supporting Information (PDF)
- CIF File (ZIP)
Publication History
Received: 04 March 2024
Accepted after revision: 25 March 2024
Article published online:
08 April 2024
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