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CC BY-NC-ND 4.0 · Eur J Pediatr Surg 2023; 33(06): 499-502
DOI: 10.1055/s-0043-1760823
Original Article

Association of Renal Function (Estimate Glomerular Filtration Rate) with the Number of Febrile Urinary Tract Infections in Children with Neurogenic Bladder

Autoren

  • Guanglun Zhou   *

    1   Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Futian District, Shenzhen, Guangdong, China

  • Man Jiang   *

    2   Department of Infectious Diseases, Department of Urology and Laboratory of Pelvic Floor Muscle Function, and Department of Clinical Laboratory, Shenzhen Children's Hospital, Shenzhen, China

  • Wenbin Zhu

    1   Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Futian District, Shenzhen, Guangdong, China

  • Xiaodong Liu

    1   Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Futian District, Shenzhen, Guangdong, China

  • Junjie Sun

    1   Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Futian District, Shenzhen, Guangdong, China

  • Shoulin Li

    1   Department of Urology and Laboratory of Pelvic Floor Muscle Function, Shenzhen Children's Hospital, Futian District, Shenzhen, Guangdong, China

Funding This study is supported by Shenzhen Fund for Guangdong Provincial High-Level Clinical Key specialties, SZXK035.
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Abstract

Introduction Our objective was to evaluate whether renal function, assessed as the estimated glomerular filtration rate (eGFR), is associated with the number of febrile urinary tract infections (FUTIs) in children diagnosed with neurogenic bladder (NB).

Materials and Methods Clinical information of patients diagnosed with NB was prospectively collected between January 2013 and January 2022. Episodes of FUTI were recorded during the follow-up period, and the eGFR was calculated based on the serum cystatin C level. Grading (G1–G5) of chronic kidney disease (CKD) was conducted as described by the eGFR.

Results In total, 463 children were included in the final analysis (265 males and 198 females; mean age: 23 months). The median follow-up time was 51 months. A total of 302 children had four or more FUTIs and 161 children had none to three FUTIs. The incidence of developing CKD G3 to G5 gradually increased from the first to third (1.3–2.4%) episodes of FUTI and drastically increased after four episodes (≥ 22.5%), with the incidence recorded to be 100% after eight FUTIs. The odds of CKD G3 to G5 in children with four FUTIs were 17.3 and 43.7 times greater after four and six FUTIs, respectively, than in children with one FUTI.

Conclusion This study showed that recurrent FUTIs are common in children with NB and that the risk of rapid progression to CKD G3 to G5 increases substantially after four or more FUTIs episodes.

Keywords

renal function - glomerular filtration rate - urinary tract infection - neurogenic bladder

* These authors contributed equally and retain the first authorship.




Publikationsverlauf

Eingereicht: 02. Dezember 2022

Angenommen: 29. November 2022

Artikel online veröffentlicht:
31. Januar 2023

© 2023. The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/)

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