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Synthesis 2023; 55(10): 1517-1524
DOI: 10.1055/s-0042-1752398
DOI: 10.1055/s-0042-1752398
paper
Oxidation of α-Trifluoromethyl and Nonfluorinated Secondary Alcohols to Ketones Using a Nitroxide Catalyst
This research was funded by the University of Connecticut Research Enhancement Program (FP) and the Department of Chemistry Charles Waring Fund (WPB).
Abstract
A methodology for the oxidation of α-trifluoromethyl alcohols to the corresponding trifluoromethyl ketones is presented. A catalytic quantity of a nitroxide is used, and potassium persulfate serves as the terminal oxidant. The methodology proves effective for aromatic, heteroaromatic, and conjugated alcohol substrates. It can be extended to nonfluorinated secondary alcohols and, in this case, can be applied to a range of aromatic, heteroaromatic, and aliphatic alcohols.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0042-1752398.
- Supporting Information
Publication History
Received: 29 October 2022
Accepted after revision: 04 January 2023
Article published online:
02 February 2023
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