Correlation Between Clinical, Endoscopic and Histological Scores Activity in Crohn’s Disease

Aims Our aim was to evaluate the correlation between clinical, endoscopic and histologic scores activity in Crohn’s disease (CD).

Methods Thirty patients with CD were included in a prospective study from June to October 2020. Patients with a history of bowel resection were not included. Clinical activity was assessed by Crohn’s Disease Activity Index (CDAI). All of the patients were submitted an ileocolonoscopy with biopsy and classified by Crohn’s Disease Endoscopic Index Score (CDEIS). Histological activity was assessed by Global Histological Activity Score (GHAS). Remission was considered with CDAI <150; CDEIS ≤2 and GHAS ≤4.

Results Thirty patients were included in our study. Mean age was 40,9 years [18.68] and sex ratio (M/W) was 1.8.Clinical remission was established in 63 %, however, only 50 % had mucosal healing (MH) and 30 % histological healing. Correlation between endoscopic and histological measures was significant (σ = 0.46, p =0,04). The concordance remission agreement between CDEIS and GHAS was moderate with (κ) = 0.44. The correlation between CDAI and CDEIS was not significant (p=0,13). The greatest disparity arose when clinical CDAI was compared with GHAS (σ = 0.23, p =0,37), (κ) = 0.21.

Conclusions According to our study, CDEIS correlates well with histological GHAS in CD, however, there is moderate concordance between both. CDAI score had low correlation and concordance with CDEIS and GHAS. In this sample, patients without symptoms had low MH and histological healing.

Citation: Ben Farhat F, Sabbah M, Bellil N etal. eP263 CORRELATION BETWEEN CLINICAL, ENDOSCOPIC AND HISTOLOGICAL SCORES ACTIVITY IN CROHN’S DISEASE. Endoscopy 2021; 53: S184.

Publication History

Article published online:
19 March 2021