Synthesis and Biological Investigation of 1,2,4-Triazolo[4,3-a]azines as Potential HSF1 Inductors

Abstract

Derivatives of fused 1,2,4-triazines containing heterocyclic and metallocene fragments were obtained by one-pot oxidative cyclization of heterocyclic hydrazones in the presence of hypervalent iodine(III) reagents. For 1,2,4-triazolo[4,3-a]azines, the ability to activate HSF1 was investigated. The obtained compounds were shown to increase the degree of HSF1 activation. It was shown that the 1,2,4-triazines can be used to induce Hsp70 expression and decrease the extent of mutant HTT aggregate formation.

Key words

azoloazine - hypervalent iodine(III) - cyclization - HSF1 inductors - heteroaromatic - metallocene

Publikationsverlauf

Eingereicht: 29. November 2021

Angenommen nach Revision: 04. Februar 2022

Artikel online veröffentlicht:
17. März 2022

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