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Synlett 2022; 33(06): 503-512
DOI: 10.1055/s-0040-1719860
DOI: 10.1055/s-0040-1719860
synpacts
Introduction to Spatial Anion Control for Direct C–H Arylation
Autor*innen
We acknowledge the funding of our research in the area of C–H activation by the Department of Chemistry, University of Zurich (UZH), the UZH Alumni – Fonds zur Förderung des akademischen Nachwuchses (FAN), the Dr. Helmut Legerlotz-Stiftung, the Prof. Dr. Hans E. Schmid-Stiftung, a Forschungskredit Postdoc UZH, the Foundation for Research in Science and the Humanities at the UZH, the Alfred Werner-Legat, the China Scholarship Council, and the Holcim Stiftung.
Abstract
C–H activation of functionally rich molecules without the need for directing groups promises shorter organic syntheses and late-stage diversification of molecules for drug discovery. We highlight recent examples of palladium-catalyzed nondirected functionalization of C–H bonds in arenes as limiting substrates with a focus on the development of the concept of spatial anion control for direct C–H arylation.
1 C–H Activation and the CMD Mechanism
2 Nondirected C–H Functionalizations of Arenes as Limiting Substrates
3 Nondirected C–H Arylation
4 Spatial Anion Control for Direct C–H Arylation
5 Coordination Chemistry with Spatial Anion Control
6 Conclusion
Key words
C–H activation - concerted metalation-deprotonation - CMD - C–H arylation - spatial anion control - palladiumPublikationsverlauf
Eingereicht: 18. Oktober 2021
Angenommen nach Revision: 23. November 2021
Artikel online veröffentlicht:
01. Februar 2022
© 2022. Thieme. All rights reserved
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