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Synthesis 2020; 52(17): 2572-2578
DOI: 10.1055/s-0040-1707397
DOI: 10.1055/s-0040-1707397
paper
Synthesis of (2S,3R,5R)-2-Azido-3,5-dihydroxynonadecane Sphingolipid Analogue
We are grateful for the financial support from the Agence Universitaire de la Francophonie (AUF), Région Bretagne, Centre national de la recherche scientifique (CNRS) (UMR 6226), and the Université de Rennes 1.
Abstract
A concise and highly efficient synthesis of an enigmol analogue has been achieved. The synthetic strategy features Jacobsen’s hydrolytic kinetic resolution (HKR) and epoxide opening by alkynyl boranes as the key steps.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0040-1707397.
- Supporting Information
Publication History
Received: 10 March 2020
Accepted: 04 May 2020
Publication Date:
18 May 2020 (online)
© Georg Thieme Verlag
Stuttgart · New York
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