Synlett 2020; 31(19): 1937-1941
DOI: 10.1055/s-0040-1707307
cluster
Integrated Synthesis Using Continuous-Flow Technologies

Accelerating Heat-Initiated Radical Reactions of Organic Halides with Tin Hydride Using Flow Microreactor Technologies

Yiyuan Jiang
,
Yosuke Ashikari
,
Kaiteng Guan
,
Aiichiro Nagaki
Kyoto University: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyotodaigaku-katsura Nishikyo-ku, Kyoto, 615-8150, Japan   Email: [email protected]
› Author Affiliations

This work was partially supported by the Japan Society for the Promotion of Science [JSPS KAKENHI, Grant Numbers JP15H05849 (Grant-in-Aid for Scientific Research on Innovative Areas 2707 middle molecular strategy), JP26288049 (Grant-in-Aid for Scientific Research (B)), JP26220804 (Grant-in-Aid for Scientific Research (S)), JP25220913 (Grant-in-Aid for Scientific Research (S)), JP17865428 (Grant-in-Aid for Scientific Research (C)), and JP20K15276 (Grant-in-Aid for Early-Career Scientists)]. This work was also partially supported by the Japan Agency for Medical Research and Development (AMED, Grant Number JP19ak0101090), the Core Research for Evolutional Science and Technology (CREST), and the Japan Science and Technology Agency’s (JST) A-step program (Adaptable and Seamless Technology Transfer Program through Target-Driven R and D, Grant Number 18067420).


Abstract

We herein report that flow microreactors can promote an efficiency of radical chain reactions. The chain reactions with a fast propagation step can be accelerated by virtue of an efficient heat-transfer character of the microreactors, whereas the yield of those reactions with a slow propagation step was increased by flow microreactors. Moreover, the yield was further increased by a sequential addition of the initiators, which was allowed by a flow-sequential-addition system.

Supporting Information



Publication History

Received: 04 August 2020

Accepted after revision: 02 September 2020

Publication Date:
09 October 2020 (online)

© 2020. Thieme. All rights reserved

Georg Thieme Verlag KG
Rüdigerstraße 14, 70469 Stuttgart, Germany

 
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