Synlett 2020; 31(16): 1613-1618
DOI: 10.1055/s-0040-1707196
letter
© Georg Thieme Verlag Stuttgart · New York

Room-Temperature Palladium(II)-Catalyzed Direct 2-Arylation of Indoles with Tetraarylstannanes

Yuxia Liu
a   Shaanxi Natural Carbohydrate Resource Engineering Research Center, College of Food Science and Technology, Northwest University, Xi’an, 710069, P. R. of China   eMail: yuxialiu@nwu.edu.cn
,
Chao Wang
b   Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, P. R. of China   eMail: c.wang@snnu.edu.cn
,
Linjuan Huang
c   Shaanxi Natural Carbohydrate Resource Engineering Research Center, College of Food Science and Technology, Northwest University, Xi’an, 710069, P. R. of China   eMail: huanglj@nwu.edu.cn
,
Dong Xue
d   Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education and School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, P. R. of China   eMail: xuedong_welcome@snnu.edu.cn
› Institutsangaben
We are grateful for the financial support of the National Natural Science Foundation of China (21902126), China Postdoctoral Science Foundation (2019M663947XB), and the 111 Project (B14041).
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Publikationsverlauf

Received: 04. Mai 2020

Accepted after revision: 14. Juni 2020

Publikationsdatum:
05. August 2020 (online)


Abstract

A palladium(II)-catalyzed direct 2-arylation of indoles by tetraarylstannanes with oxygen (balloon) as the oxidant at room temperature has been developed. Various tetraarylstannanes can be employed as aryl sources for 2-arylation of indoles in up to 89% yield, providing a practical and efficient catalytic protocol for accessing 2-arylindoles.

Supporting Information