Synlett
DOI: 10.1055/s-0040-1707109
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© Georg Thieme Verlag Stuttgart · New York

Facile C–S Bond Cleavage of Aryl Sulfoxides Promoted by Brønsted Acid

Bogdan R. Brutiu
,
Immo Klose
,
We thank the Österreichischen Akademie der Wissenschaften (Austrian Academy of Sciences) (DOC Fellowship to I.K.) and the H2020 European Research Council (ERC Consolidator Grant VINCAT, 682002) for support of this research. Continued generous support of our research programs by Universität Wien (University of Vienna) is gratefully acknowledged.
Further Information

Publication History

Received: 14 March 2020

Accepted after revision: 15 April 2020

Publication Date:
06 May 2020 (online)


Dedicated with respect and admiration to Prof. Barry M. Trost, a founding member of Science of Synthesis, on the occasion of the 20th anniversary of Science of Synthesis.

‡ These authors contributed equally to this work

Abstract

A method for the Brønsted acid promoted desulfination of aryl sulfoxides is presented. In the presence of a thiol, electron-rich sulfoxides undergo C–S bond cleavage to give the corresponding protodesulfinated arenes and disulfides.

Supporting Information

 
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