Synthesis 2021; 53(10): 1842-1848
DOI: 10.1055/s-0040-1706662
paper

Nickel-Catalyzed Intramolecular Nucleophilic Addition of Aryl Halides to Aryl Ketones for the Synthesis of Benzofuran Derivatives

Xiao-Rui Zhu
a  College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China
,
Chen-Liang Deng
a  College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. of China
b  Institute of New Materials & Industry Technology, Wenzhou University, Wenzhou 325035, P. R. of China
› Author Affiliations
We thank the National Natural Science Foundation of China (No. 21102104) and Wenzhou Science & Technology Bureau (No. G20190029) for their financial support.


Abstract

A nickel-catalyzed intramolecular nucleophilic addition reaction of aryl halides to aryl ketones for the formation of benzofuran derivatives has been developed. A number of substrates bearing electron-donating or electron-withdrawing groups were subjected to the standard reaction conditions, giving the corresponding products in moderate to good yields.

Supporting Information



Publication History

Received: 10 November 2020

Accepted after revision: 11 December 2020

Publication Date:
25 January 2021 (online)

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