Synlett 2021; 32(06): 611-615
DOI: 10.1055/s-0040-1706641
letter

Efficient Copper-Catalysed Synthesis of Carbazoles by Double N-Arylation of Primary Amines with 2,2′-Dibromobiphenyl in the Presence of Air

Authors

  • Ha Nam Do

    a   Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU), 19-Le Thanh Tong, Hanoi, Vietnam
  • Nguyen Minh Quan

    b   Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam
  • Ban Van Phuc

    c   Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam
  • Dinh Van Tinh

    d   Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
  • Nguyen Quyet Tien

    c   Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam
  • Truong Thi Thanh Nga

    c   Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam
  • Van Tuyen Nguyen

    b   Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam
    c   Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam
  • Tran Quang Hung

    b   Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam
    c   Institute of Chemistry, Vietnam Academy of Science and Technology, 18-Hoang Quoc Viet, Hanoi, Vietnam
  • Tuan Thanh Dang

    a   Faculty of Chemistry, Hanoi University of Science, Vietnam National University (VNU), 19-Le Thanh Tong, Hanoi, Vietnam
  • Peter Langer

    d   Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany
    e   Leibniz Institut für Katalyse an der Universität Rostock e.V., Albert-Einstein-Str. 3a, 18059 Rostock, Germany

This research was supported by the Institute of Chemistry of the VAST (Grant Number VHH.2020.1.01).


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Abstract

An efficient Cu-catalyzed synthesis of carbazole derivatives is reported, which proceeds by double C–N coupling reactions of 2,2′-dibromobiphenyl and amines in the presence of air. The reaction is robust, proceeds in high yields, and tolerates a series of amines including neutral, electron-rich, electron-deficient aromatic amines and aliphatic amines.

Supporting Information



Publikationsverlauf

Eingereicht: 24. September 2020

Angenommen nach Revision: 13. November 2020

Artikel online veröffentlicht:
08. Januar 2021

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