Synthesis 2021; 53(11): 1955-1961
DOI: 10.1055/s-0040-1705998
paper

Simple Synthesis of Substituted 3-Hydroxyfuran-2(5H)-ones

Natalya Yu. Lisovenko
,
Ekaterina R. Nasibullina
,
Svetlana S. Kharitonova
,
Olga A. Myshkina
The reported study was funded by the Russian Foundation for Basic Research (RFBR; research project no 17-43-590653).


Abstract

A convenient and facile approach to functionalized 4-substituted 3,5-dihydroxy-5-(trichloromethyl)furan-2(5H)-ones was developed. This method is based on regioselective synthesis of novel furan-2,3-diones containing the trichloromethyl group and subsequent hydrolysis. The structures of compounds were unambiguously confirmed by single-crystal X-ray diffraction.

Supporting Information



Publication History

Received: 17 October 2020

Accepted after revision: 19 November 2020

Article published online:
11 January 2021

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