Synlett 2020; 31(19): 1942-1946
DOI: 10.1055/s-0040-1705945
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Integrated Synthesis Using Continuous-Flow Technologies

Subsupercritical Water Generated by Inductive Heating Inside Flow Reactors Facilitates the Claisen Rearrangement

Mona Oltmanns
,
Institut für Organische Chemie und Biomolekulares Wirkstoffzentrum (BMWZ) der Leibniz Universität Hannover, Schneiderberg 1B, 30167 Hannover, Germany
› Author Affiliations

This work was supported in part by the Symrise AG, Holzminden, Germany.


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Abstract

Claisen rearrangement of electron-deficient O-allylated phenols, including fluorine-modified phenols, is facilitated in aqueous media at high temperatures and pressures under flow conditions, as opposed to organic solvents. The O-allylation of phenols can be coupled with the Claisen rearrangement in an integrated flow system.

Supporting Information



Publication History

Received: 14 August 2020

Accepted after revision: 16 September 2020

Article published online:
27 October 2020

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