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Eur J Pediatr Surg 2020; 30(02): 150-155
DOI: 10.1055/s-0040-1702139
Review Article
Georg Thieme Verlag KG Stuttgart · New York

Laparoscopic Fundoplication for the Surgical Management of Gastroesophageal Reflux Disease in Children

Charlene Dekonenko
1   Department of Surgery, Children's Mercy Hospital, Kansas City, Missouri, United States
,
George W. Holcomb III
1   Department of Surgery, Children's Mercy Hospital, Kansas City, Missouri, United States
› Author Affiliations
Further Information

Publication History

06 January 2020

07 January 2020

Publication Date:
04 March 2020 (online)

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Abstract

Gastroesophageal reflux (GER) is common in infants generally resolving in early childhood. However, gastroesophageal reflux disease (GERD) is diagnosed when persistent troublesome symptoms and/or complications of GER develop. These symptoms and complications can significantly affect the quality of life, thus requiring medical or surgical treatment. Medical management is typically trialed, but operative treatment is indicated with severe symptoms such as aspiration pneumonia, apneic episodes, bradycardia, apparent life-threatening events, severe vomiting, failure to thrive, esophagitis, stricture, and failed medical therapy. We review the recent literature on the indications and outcomes for laparoscopic fundoplication in the management of pediatric GERD.

Keywords

fundoplication - gastroesophageal reflux - gastroesophageal reflux disease - laparoscopic
 

  • References

  • 1 Davies I, Burman-Roy S, Murphy MS. ; Guideline Development Group. Gastro-oesophageal reflux disease in children: NICE guidance. BMJ 2015; 350: g7703
    PubMedGoogle Scholar
  • 2 Jancelewicz T, Lopez ME, Downard CD. , et al. Surgical management of gastroesophageal reflux disease (GERD) in children: a systematic review. J Pediatr Surg 2017; 52 (08) 1228-1238
    CrossrefPubMedGoogle Scholar
  • 3 Rosen R, Vandenplas Y, Singendonk M. , et al. Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2018; 66 (03) 516-554
    CrossrefPubMedGoogle Scholar
  • 4 Vandenplas Y, Rudolph CD, Di Lorenzo C. , et al; North American Society for Pediatric Gastroenterology Hepatology and Nutrition; European Society for Pediatric Gastroenterology Hepatology and Nutrition. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr 2009; 49 (04) 498-547
    CrossrefPubMedGoogle Scholar
  • 5 Safe M, Cho J, Krishnan U. Combined multichannel intraluminal impedance and ph measurement in detecting gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr 2016; 63 (05) e98-e106
    CrossrefPubMedGoogle Scholar
  • 6 Mousa HM, Rosen R, Woodley FW. , et al. Esophageal impedance monitoring for gastroesophageal reflux. J Pediatr Gastroenterol Nutr 2011; 52 (02) 129-139
    CrossrefPubMedGoogle Scholar
  • 7 Wakeman DS, Wilson NA, Warner BW. Current status of surgical management of gastroesophageal reflux in children. Curr Opin Pediatr 2016; 28 (03) 356-362
    CrossrefPubMedGoogle Scholar
  • 8 Fike FB, Pettiford JN, St Peter SD, Cocjin J, Laituri CA, Ostlie DJ. Utility of pH/multichannel intraluminal impedance probe in identifying operative patients in infants with gastroesophageal reflux disease. J Laparoendosc Adv Surg Tech A 2012; 22 (05) 518-520
    CrossrefPubMedGoogle Scholar
  • 9 Yoo BG, Yang HK, Lee YJ, Byun SY, Kim HY, Park JH. Fundoplication in neonates and infants with primary gastroesophageal reflux. Pediatr Gastroenterol Hepatol Nutr 2014; 17 (02) 93-97
    CrossrefPubMedGoogle Scholar
  • 10 Valusek PA, St Peter SD, Tsao K, Spilde TL, Ostlie DJ, Holcomb III GW. The use of fundoplication for prevention of apparent life-threatening events. J Pediatr Surg 2007; 42 (06) 1022-1024
    CrossrefPubMedGoogle Scholar
  • 11 Ostlie DJ, Miller KA, Holcomb III GW. Effective Nissen fundoplication length and bougie diameter size in young children undergoing laparoscopic Nissen fundoplication. J Pediatr Surg 2002; 37 (12) 1664-1666
    CrossrefPubMedGoogle Scholar
  • 12 St Peter SD, Barnhart DC, Ostlie DJ. , et al. Minimal vs extensive esophageal mobilization during laparoscopic fundoplication: a prospective randomized trial. J Pediatr Surg 2011; 46 (01) 163-168
    CrossrefPubMedGoogle Scholar
  • 13 Desai AA, Alemayehu H, Holcomb III GW, St Peter SD. Minimal vs. maximal esophageal dissection and mobilization during laparoscopic fundoplication: long-term follow-up from a prospective, randomized trial. J Pediatr Surg 2015; 50 (01) 111-114
    CrossrefPubMedGoogle Scholar
  • 14 St. Peter SD, Poola A, Adibe O. , et al. Are esophagocrural sutures necessary during a laparoscopic fundoplication: a prospective randomized trial. J Pediatr Surg 2018; 53: 25-29
    CrossrefPubMedGoogle Scholar
  • 15 Georgeson K, Owings E. Surgical and laparoscopic techniques for feeding tube placement. Gastrointest Endosc Clin N Am 1998; 8 (03) 581-592
    CrossrefPubMedGoogle Scholar
  • 16 Aprahamian CJ, Morgan TL, Harmon CM, Georgeson KE, Barnhart DC. U-stitch laparoscopic gastrostomy technique has a low rate of complications and allows primary button placement: experience with 461 pediatric procedures. J Laparoendosc Adv Surg Tech A 2006; 16 (06) 643-649
    CrossrefPubMedGoogle Scholar
  • 17 Ostlie DJ, Miller KA, Woods RK, Holcomb III GW. Single cannula technique and robotic telescopic assistance in infants and children who require laparoscopic Nissen fundoplication. J Pediatr Surg 2003; 38 (01) 111-115
    CrossrefPubMedGoogle Scholar
  • 18 St Peter SD, Valusek PA, Calkins CM, Shew SB, Ostlie DJ, Holcomb III GW. Use of esophagocrural sutures and minimal esophageal dissection reduces the incidence of postoperative transmigration of laparoscopic Nissen fundoplication wrap. J Pediatr Surg 2007; 42 (01) 25-29
    CrossrefPubMedGoogle Scholar
  • 19 Holcomb III GW. Gastroesophageal reflux in infants and children. In: Fischer JE, ed. Mastery of Surgery, 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2012: 769-780
    Google Scholar
  • 20 Ostlie DJ, St Peter SD, Snyder CL, Sharp RJ, Andrews WS, Holcomb III GW. A financial analysis of pediatric laparoscopic versus open fundoplication. J Laparoendosc Adv Surg Tech A 2007; 17 (04) 493-496
    CrossrefPubMedGoogle Scholar
  • 21 Barsness KA, St Peter SD, Holcomb III GW, Ostlie DJ, Kane TD. Laparoscopic fundoplication after previous open abdominal operations in infants and children. J Laparoendosc Adv Surg Tech A 2009; 19 (Suppl. 01) S47-S49
    CrossrefPubMedGoogle Scholar
  • 22 Pacilli M, Eaton S, McHoney M. , et al. Four year follow-up of a randomised controlled trial comparing open and laparoscopic Nissen fundoplication in children. Arch Dis Child 2014; 99 (06) 516-521
    CrossrefPubMedGoogle Scholar
  • 23 Fyhn TJ, Knatten CK, Edwin B. , et al. Randomized controlled trial of laparoscopic and open Nissen fundoplication in children. Ann Surg 2015; 261 (06) 1061-1067
    CrossrefPubMedGoogle Scholar
  • 24 Leung L, Wong CW, Chung PH, Wong KK, Tam PK. Laparoscopic Nissen fundoplication for gastro-oesophageal reflux disease in infants. Pediatr Surg Int 2015; 31 (01) 83-88
    CrossrefPubMedGoogle Scholar
  • 25 Ru W, Wu P, Feng S, Lai XH, Chen G. Laparoscopic versus open Nissen fundoplication in children: a systematic review and meta-analysis. J Pediatr Surg 2016; 51 (10) 1731-1736
    CrossrefPubMedGoogle Scholar
  • 26 Zhang P, Tian J, Jing L, Wang Q, Tian J, Lun L. Laparoscopic vs. open Nissen's fundoplication for gastro-oesophageal reflux disease in children: a meta-analysis. Int J Surg 2016; 34: 10-16
    CrossrefPubMedGoogle Scholar
  • 27 Ponsky TA, Gasior AC, Parry J. , et al. Need for subsequent fundoplication after gastrostomy based on patient characteristics. J Surg Res 2013; 179 (01) 1-4
    CrossrefPubMedGoogle Scholar
  • 28 Viswanath N, Wong D, Channappa D, Kukkady A, Brown S, Samarakkody U. Is prophylactic fundoplication necessary in neurologically impaired children?. Eur J Pediatr Surg 2010; 20 (04) 226-229
    Article in Thieme ConnectPubMedGoogle Scholar
  • 29 Lintula H, Juvonen P, Hämynen I, Heikkinen M, Eskelinen M. Severe gastro-oesophageal reflux necessitating fundoplication after percutaneous endoscopic and open gastrostomy in children. Langenbecks Arch Surg 2013; 398 (05) 703-707
    CrossrefPubMedGoogle Scholar
  • 30 Kawahara H, Tazuke Y, Soh H, Yoneda A, Fukuzawa M. Does laparoscopy-aided gastrostomy placement improve or worsen gastroesophageal reflux in patients with neurological impairment?. J Pediatr Surg 2014; 49 (12) 1742-1745
    CrossrefPubMedGoogle Scholar
  • 31 Fasching G, Huber A, Uray E, Sorantin E, Lindbichler F, Mayr J. Gastroesophageal reflux and diaphragmatic motility after repair of congenital diaphragmatic hernia. Eur J Pediatr Surg 2000; 10 (06) 360-364
    Article in Thieme ConnectPubMedGoogle Scholar
  • 32 Engelmann C, Gritsa S, Gratz KF, Ure BM. Laparoscopic anterior hemifundoplication improves key symptoms without impact on GE in children with and children without neurodevelopmental delays. J Pediatr Gastroenterol Nutr 2010; 51 (04) 437-442
    CrossrefPubMedGoogle Scholar
  • 33 Engelmann C, Gritsa S, Ure BM. Impact of laparoscopic anterior 270 degrees fundoplication on the quality of life and symptoms profile of neurodevelopmentally delayed versus neurologically unimpaired children and their parents. Surg Endosc 2010; 24 (06) 1287-1295
    CrossrefPubMedGoogle Scholar
  • 34 Heinrich M, Kain A, Bergmann F, von Schweinitz D. Parents reported reduced symptoms and improved satisfaction after fundoplication and their perceptions were an important outcome measure. Acta Paediatr 2017; 106 (01) 168-173
    CrossrefPubMedGoogle Scholar
  • 35 Knatten CK, Kvello M, Fyhn TJ. , et al. Nissen fundoplication in children with and without neurological impairment: a prospective cohort study. J Pediatr Surg 2016; 51 (07) 1115-1121
    CrossrefPubMedGoogle Scholar
  • 36 Mauritz FA, Stellato RK, van Heurn LWE. , et al. Laparoscopic antireflux surgery increases health-related quality of life in children with GERD. Surg Endosc 2017; 31 (08) 3122-3129
    CrossrefPubMedGoogle Scholar
  • 37 Lin DC, Chun CL, Triadafilopoulos G. Evaluation and management of patients with symptoms after anti-reflux surgery. Dis Esophagus 2015; 28 (01) 1-10
    CrossrefPubMedGoogle Scholar
  • 38 Baerg J, Thorpe D, Gasior A, Vannix R, Tagge E, St Peter S. Factors associated with mortality after Nissen fundoplication in children. Eur J Pediatr Surg 2015; 25 (03) 277-283
    Article in Thieme ConnectPubMedGoogle Scholar
  • 39 Desai AA, Alemayehu H, Dalton BG. , et al. Review of the experience with re-operation after laparoscopic Nissen fundoplication. J Laparoendosc Adv Surg Tech A 2016; 26 (02) 140-143
    CrossrefPubMedGoogle Scholar
  • 40 Koivusalo AI, Pakarinen MP. Outcome of surgery for pediatric gastroesophageal reflux: clinical and endoscopic follow-up after 300 fundoplications in 279 consecutive patients. Scand J Surg 2018; 107 (01) 68-75
    CrossrefPubMedGoogle Scholar
  • 41 Holcomb III GW. “Gastroesophageal reflux.”. In: Holcomb III GW, Murphy JP, St. Peter SD. , eds. Holcomb and Ashcraft's Pediatric Surgery, 7th ed. St. Louis: Elsevier Inc.; 2020: 460-477
    Google Scholar
  • 42 Ostlie DJ, Holcomb III GW. Reiterative laparoscopic surgery for recurrent gastroesophageal reflux. Semin Pediatr Surg 2007; 16 (04) 252-258
    CrossrefPubMedGoogle Scholar
  • 43 St Peter SD, Ostlie DJ, Holcomb III GW. The use of biosynthetic mesh to enhance hiatal repair at the time of redo Nissen fundoplication. J Pediatr Surg 2007; 42 (07) 1298-1301
    CrossrefPubMedGoogle Scholar
  • 44 Bansal S, Rothenberg SS. Evaluation of laparoscopic management of recurrent gastroesophageal reflux disease and hiatal hernia: long term results and evaluation of changing trends. J Pediatr Surg 2014; 49 (01) 72-75
    CrossrefPubMedGoogle Scholar
  • 45 Fukahori S, Yagi M, Ishii S. , et al. Laparoscopic Nissen fundoplication mainly reduces the volume of acid reflux and potentially improves mucosal integrity up to the middle esophagus in neurologically impaired children detected by esophageal combined pH-multichannel intraluminal impedance measurements. J Pediatr Surg 2016; 51 (08) 1283-1287
    CrossrefPubMedGoogle Scholar
  • 46 Ireland AC, Holloway RH, Toouli J, Dent J. Mechanisms underlying the antireflux action of fundoplication. Gut 1993; 34 (03) 303-308
    CrossrefPubMedGoogle Scholar
  • 47 Straathof JW, Ringers J, Masclee AA. Prospective study of the effect of laparoscopic Nissen fundoplication on reflux mechanisms. Br J Surg 2001; 88 (11) 1519-1524
    CrossrefPubMedGoogle Scholar
  • 48 Sarani B, Chan T, Wise R, Evans S. Nissen fundoplication has a vagolytic effect on the lower esophageal sphincter. Surg Endosc 2003; 17 (08) 1206-1211
    CrossrefPubMedGoogle Scholar
  • 49 Holcomb III. Laparoscopic Nissen fundoplication. In: Holcomb GWIII, Georgeson KE, Rothenberg SS. , eds. Atlas of Pediatric Laparoscopy and Thoracoscopy. Philadelphia: Elsevier; 2008: 15-20
    CrossrefGoogle Scholar