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Am J Perinatol 2020; 37(11): 1140-1145
DOI: 10.1055/s-0039-1692454
Original Article

Evaluating Relationships between Visceral Fat Measures and Adipokines Concentrations among Women with a History of Preeclampsia

Suchitra Chandrasekaran
1   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington
,
Darcy Barry
2   Eastside Maternal-Fetal Medicine–Evergreen Health, Seattle, Washington
,
Susan Melhorn
3   Division of General Internal Medicine, University of Washington, Seattle, Washington
,
Thomas Easterling
1   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington
,
Hilary Gammill
1   Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington
,
Ellen Schur
3   Division of General Internal Medicine, University of Washington, Seattle, Washington
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Abstract

Objective We sought to evaluate associations between postpartum plasma adipokine concentrations among women with a history of preeclampsia (PE) without severe features (MPE), PE with severe features (SPE), and no PE (NPE). We also investigated relationships between adipokines and computed tomography (CT)-quantified measures of visceral fat (VF) area (VFA) and subcutaneous fat area (SCFA).

Study Design We performed a secondary analysis of data collected as part of a previously performed cross-sectional study at our institution. Women with and without a history of PE were recruited in 10 years after delivery. VFA and SCFA measures were performed by CT scan. Anthropometric data and peripheral blood samples from subjects were collected concurrently.

Results Plasma adiponectin concentrations (µg/mL) were significantly lower among MPE (18.5 ± 7.1) compared with NPE (27.3 ± 13.8) and SPE (25.7 ± 9.6). Leptin (p = 0.32) and resistin (p = 0.93) concentrations were similar among the groups. Adiponectin concentrations more closely aligned with VFA (β = −0.001, p = 0.03), while resistin concentrations trended toward correlating with SCFA (β = 0.02, p = 0.05). Leptin was not preferential to VFA or SCFA.

Conclusion VF distribution may contribute to the variation in PE phenotype. Adiponectin specifically may be a promising marker representing VFA.

Keywords

preeclampsia - obesity - visceral fat - adipokines


Publication History

Received: 21 December 2018

Accepted: 06 May 2019

Article published online:
06 June 2019

© 2020. Thieme. All rights reserved.

Thieme Medical Publishers
333 Seventh Avenue, New York, NY 10001, USA.

 

  • References

  • 1 American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 125: chronic hypertension in pregnancy. Obstet Gynecol 2012; 119 (2 Pt 1): 396-407
    CrossrefPubMedGoogle Scholar
  • 2 American College of Obstetricians and Gynecologists; Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Obstet Gynecol 2013; 122 (05) 1122-1131
    CrossrefPubMedGoogle Scholar
  • 3 D'Alton ME, Main EK, Menard MK, Levy BS. The national partnership for maternal safety. Obstet Gynecol 2014; 123 (05) 973-977
    CrossrefPubMedGoogle Scholar
  • 4 Fingar KR, Mabry-Hernandez I, Ngo-Metzger Q, Wolff T, Steiner CA, Elixhauser A. Delivery Hospitalizations Involving Preeclampsia and Eclampsia, 2005–2014: Statistical Brief #222. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs. Rockville (MD): Agency for Healthcare Research and Quality (US); 2006
    Google Scholar
  • 5 Dietz WH. The response of the US Centers for Disease Control and Prevention to the obesity epidemic. Annu Rev Public Health 2015; 36: 575-596
    CrossrefPubMedGoogle Scholar
  • 6 Overcash RT, Lacoursiere DY. The clinical approach to obesity in pregnancy. Clin Obstet Gynecol 2014; 57 (03) 485-500
    CrossrefPubMedGoogle Scholar
  • 7 Roberts JM, Bodnar LM, Patrick TE, Powers RW. The role of obesity in preeclampsia. Pregnancy Hypertens 2011; 1 (01) 6-16
    CrossrefPubMedGoogle Scholar
  • 8 Huda SS, Brodie LE, Sattar N. Obesity in pregnancy: prevalence and metabolic consequences. Semin Fetal Neonatal Med 2010; 15 (02) 70-76
    CrossrefPubMedGoogle Scholar
  • 9 Rasmussen KM, Abrams B, Bodnar LM, Butte NF, Catalano PM, Maria Siega-Riz A. Recommendations for weight gain during pregnancy in the context of the obesity epidemic. Obstet Gynecol 2010; 116 (05) 1191-1195
    CrossrefPubMedGoogle Scholar
  • 10 Rasmussen KM, Catalano PM, Yaktine AL. New guidelines for weight gain during pregnancy: what obstetrician/gynecologists should know. Curr Opin Obstet Gynecol 2009; 21 (06) 521-526
    CrossrefPubMedGoogle Scholar
  • 11 Weiss JL, Malone FD, Emig D. , et al; FASTER Research Consortium. Obesity, obstetric complications and cesarean delivery rate--a population-based screening study. Am J Obstet Gynecol 2004; 190 (04) 1091-1097
    CrossrefPubMedGoogle Scholar
  • 12 Barry DR, Utzschneider KM, Tong J. , et al. Intraabdominal fat, insulin sensitivity, and cardiovascular risk factors in postpartum women with a history of preeclampsia. Am J Obstet Gynecol 2015; 213 (01) 104.e1-104.e11
    CrossrefPubMedGoogle Scholar
  • 13 Kanai H, Tokunaga K, Fujioka S, Yamashita S, Kameda-Takemura KK, Matsuzawa Y. Decrease in intra-abdominal visceral fat may reduce blood pressure in obese hypertensive women. Hypertension 1996; 27 (01) 125-129
    CrossrefPubMedGoogle Scholar
  • 14 Diaz AA, Young TP, Kurugol S. , et al; COPDGene investigators. Abdominal visceral adipose tissue is associated with myocardial infarction in patients with COPD. Chronic Obstr Pulm Dis (Miami) 2015; 2 (01) 8-16
    PubMedGoogle Scholar
  • 15 Katsuki A, Sumida Y, Urakawa H. , et al. Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance. Diabetes Care 2003; 26 (08) 2341-2344
    CrossrefPubMedGoogle Scholar
  • 16 Utzschneider KM, Carr DB, Hull RL. , et al. Impact of intra-abdominal fat and age on insulin sensitivity and beta-cell function. Diabetes 2004; 53 (11) 2867-2872
    CrossrefPubMedGoogle Scholar
  • 17 Taylor RW, Goulding A. Plasma leptin in relation to regional body fat in older New Zealand women. Aust N Z J Med 1998; 28 (03) 316-321
    CrossrefPubMedGoogle Scholar
  • 18 Schur EA, Melhorn SJ, Oh SK. , et al. Radiologic evidence that hypothalamic gliosis is associated with obesity and insulin resistance in humans. Obesity (Silver Spring) 2015; 23 (11) 2142-2148
    CrossrefPubMedGoogle Scholar
  • 19 Schwartz RS, Shuman WP, Larson V. , et al. The effect of intensive endurance exercise training on body fat distribution in young and older men. Metabolism 1991; 40 (05) 545-551
    CrossrefPubMedGoogle Scholar
  • 20 Bosch TA, Chow L, Dengel DR. , et al. In adult twins, visceral fat accumulation depends more on exceeding sex-specific adiposity thresholds than on genetics. Metabolism 2015; 64 (09) 991-998
    CrossrefPubMedGoogle Scholar
  • 21 Doster Y, Cetinkaya Demir B, Atalay MA, Durusoy EE, Kucukkomurcu S. The possible role of serum leptin in preeclampsia. Clin Exp Obstet Gynecol 2016; 43 (01) 98-102
    CrossrefPubMedGoogle Scholar
  • 22 Martínez-Abundis E, González-Ortiz M, Pascoe-González S. Serum leptin levels and the severity of preeclampsia. Arch Gynecol Obstet 2000; 264 (02) 71-73
    CrossrefPubMedGoogle Scholar
  • 23 Koçyigit Y, Atamer Y, Atamer A, Tuzcu A, Akkus Z. Changes in serum levels of leptin, cytokines and lipoprotein in pre-eclamptic and normotensive pregnant women. Gynecol Endocrinol 2004; 19 (05) 267-273
    CrossrefPubMedGoogle Scholar
  • 24 Kocyigit Y, Bayhan G, Atamer A, Atamer Y. Serum levels of leptin, insulin-like growth factor-I and insulin-like growth factor binding protein-3 in women with pre-eclampsia, and their relationship to insulin resistance. Gynecol Endocrinol 2004; 18 (06) 341-348
    CrossrefPubMedGoogle Scholar
  • 25 Williams MA, Havel PJ, Schwartz MW. , et al. Pre-eclampsia disrupts the normal relationship between serum leptin concentrations and adiposity in pregnant women. Paediatr Perinat Epidemiol 1999; 13 (02) 190-204
    CrossrefPubMedGoogle Scholar
  • 26 Hendler I, Blackwell SC, Mehta SH. , et al. The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia. Am J Obstet Gynecol 2005; 193 (3 Pt 2): 979-983
    CrossrefPubMedGoogle Scholar
  • 27 Iftikhar U, Khoja A, , Mehjabeen, Iqbal A, Karira KA. Evaluation of serum leptin levels during normal pregnancy and in pre-eclampsia. J Ayub Med Coll Abbottabad 2008; 20 (04) 137-140
    PubMedGoogle Scholar
  • 28 Mumtaz F, Memon AR, Yousfani S. , et al. Role of serum leptin level as a marker of severity of pre eclampsia. J Ayub Med Coll Abbottabad 2008; 20 (01) 13-15
    PubMedGoogle Scholar
  • 29 Song Y, Gao J, Qu Y, Wang S, Wang X, Liu J. Serum levels of leptin, adiponectin and resistin in relation to clinical characteristics in normal pregnancy and preeclampsia. Clin Chim Acta 2016; 458: 133-137
    CrossrefPubMedGoogle Scholar
  • 30 Founds SA, Tsigas E, Ren D, Barmada MM. Associating symptom phenotype and genotype in preeclampsia. Biol Res Nurs 2018; 20 (02) 126-136
    CrossrefPubMedGoogle Scholar
  • 31 Fong FM, Sahemey MK, Hamedi G. , et al. Maternal genotype and severe preeclampsia: a HuGE review. Am J Epidemiol 2014; 180 (04) 335-345
    CrossrefPubMedGoogle Scholar
  • 32 Huda SS, Jordan F, Bray J. , et al. Visceral adipose tissue activated macrophage content and inflammatory adipokine secretion is higher in pre-eclampsia than in healthy pregnancys. Clin Sci (Lond) 2017; 131 (13) 1529-1540
    CrossrefPubMedGoogle Scholar
  • 33 Bro Schmidt G, Christensen M, Breth Knudsen U. Preeclampsia and later cardiovascular disease - what do national guidelines recommend?. Pregnancy Hypertens 2017; 10: 14-17
    CrossrefPubMedGoogle Scholar
  • 34 Brouwers L, van der Meiden-van Roest AJ, Savelkoul C. , et al. Recurrence of pre-eclampsia and the risk of future hypertension and cardiovascular disease: a systematic review and meta-analysis. BJOG 2018; 125 (13) 1642-1654
    CrossrefPubMedGoogle Scholar
  • 35 Lisowska M, Pietrucha T, Sakowicz A. Preeclampsia and related cardiovascular risk: common genetic background. Curr Hypertens Rep 2018; 20 (08) 71
    CrossrefPubMedGoogle Scholar