Synlett 2020; 31(03): 280-284
DOI: 10.1055/s-0039-1691538
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Phenanthridinones by Palladium-Catalyzed Cyclization of N-Aryl-2-aminopyridines with 2-Iodobenzoic Acids in Water

Authors

  • Xiaojuan Ding

    a   College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, P. R. of China   eMail: duanjd@njtech.edu.cn   eMail: guok@njtech.edu.cn
  • Lei Zhang

    a   College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, P. R. of China   eMail: duanjd@njtech.edu.cn   eMail: guok@njtech.edu.cn
  • Yiyang Mao

    a   College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, P. R. of China   eMail: duanjd@njtech.edu.cn   eMail: guok@njtech.edu.cn
  • Binsen Rong

    a   College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, P. R. of China   eMail: duanjd@njtech.edu.cn   eMail: guok@njtech.edu.cn
  • Ning Zhu

    a   College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, P. R. of China   eMail: duanjd@njtech.edu.cn   eMail: guok@njtech.edu.cn
  • Jindian Duan

    a   College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, P. R. of China   eMail: duanjd@njtech.edu.cn   eMail: guok@njtech.edu.cn
  • Kai Guo

    a   College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, P. R. of China   eMail: duanjd@njtech.edu.cn   eMail: guok@njtech.edu.cn
    b   State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, 30 Puzhu Rd S., Nanjing 211816, P. R. of China

Financial support for this study from the Jiangsu Synergetic Innovation Center for Advanced Bio-Manufacture (NO.XTE1826) and the Natural Science Research of Jiangsu Higher Education Institutions of China (19KJB150027) is gratefully acknowledged.
Weitere Informationen

Publikationsverlauf

Received: 13. Oktober 2019

Accepted after revision: 03. Dezember 2019

Publikationsdatum:
16. Dezember 2019 (online)


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Abstract

The first Pd-catalyzed cyclization of N-aryl-2-aminopyridines with 2-iodobenzoic acids for the synthesis of phenanthridinones through C–H bond activation under very low catalyst loadings (down to 0.1 mol% Pd) in water is reported. This protocol features a broad substrate scope and provides easy efficient access to various phenanthridinones.

Supporting Information