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Synthesis 2020; 52(11): 1680-1686
DOI: 10.1055/s-0039-1690871
DOI: 10.1055/s-0039-1690871
paper
Palladium-Catalyzed Cascade Synthesis of Novel Quinolone- Bis(indolyl)methane Hybrids as Promising α-Glucosidase Inhibitors
Authors
The work was financially supported by NSFC (No. 21762014) and Guizhou Provincial Engineering Research Center for Natural Drugs.
Further Information
Publication History
Received: 14 February 2020
Accepted after revision: 10 March 2020
Publication Date:
30 March 2020 (online)
§ These authors contributed equally to this work
Abstract
An unexpected cascade reaction is developed for the construction of functionalized 3-bis(indol-3-yl)methylquinoline-2(1H)-ones. Three C–C bonds and one ring are created in one pot triggered by Pd-catalyzed C-3 alkenylation of indole with 2-acyl-N-acrylaniline derivatives. A series of complex and specific quinoline-2(1H)-ones were produced, most of them showed significant α-glucosidase inhibitory activities.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690871.
- Supporting Information (PDF)
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