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Synlett 2020; 31(08): 801-804
DOI: 10.1055/s-0039-1690835
DOI: 10.1055/s-0039-1690835
letter
Copper-Promoted Coupling of Propiophenones and Arylhydrazines for the Synthesis of 1,3-Diarylpyrazoles
Authors
This research is funded by the Ho Chi Minh City University of Technology – VNU-HCM (grant number T-KTHH-2018-100).
Weitere Informationen
Publikationsverlauf
Received: 19. Januar 2020
Accepted after revision: 04. Februar 2020
Publikationsdatum:
26. Februar 2020 (online)
Abstract
Synthesis of 1,3-diarylpyrazoles from commercial substrates and/or simple transformations is still underrated. In this report, we have developed a method for copper-promoted coupling of propiophenones and arylhydrazines. The reactions afforded substituted pyrazoles in the presence of TEMPO oxidant, acetic acid additive, and DMF solvent. A number of functionalities were compatible with reaction conditions, including halogens, methoxy, trifluoromethyl, and nitro groups. An indazole could be obtained if an electron-poor propiophenone was used.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0039-1690835.
- Supporting Information (PDF)
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