Synthesis 2020; 52(02): 281-289
DOI: 10.1055/s-0039-1690731
paper
© Georg Thieme Verlag Stuttgart · New York

Efficient Synthesis of Diarylmethylamines via Lewis Acid Catalyzed Friedel–Crafts Reactions of Donor–Acceptor Aziridines with N,N-Dialkylanilines

Yerin Kim
,
Yong Il Kwon
,
Sung-Gon Kim
Department of Chemistry, Kyonggi University, 154-42 Gwanggyosan-ro, Yeongtong-gu, Suwon 16227, Republic of Korea   Email: sgkim123@kyonggi.ac.kr
› Author Affiliations
This research was supported by the Nanomaterial Technology Development Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2012M3A7B4049645) and the Basic Science Research Program through NRF funded by the Ministry of Education (NRF-2016R1D1A1A09916621), and by Kyonggi University's Graduate Research Assistant Fellowship 2019.
Further Information

Publication History

Received: 02 August 2019

Accepted after revision: 08 October 2019

Publication Date:
29 October 2019 (online)


Abstract

A method for efficient and mild synthesis of diarylmethylamine scaffold, via Lewis acid catalyzed Friedel–Crafts reaction of donor­–acceptor aziridines with N,N-dialkylanilines to afford a biologically important diarylmethylamine derivatives in high yields (up to 88%), is presented. This reaction is suitable for the synthesis of various diarylmethylamine derivatives and has a broad scope for electron-rich arenes, including dimethoxybenzene.

Supporting Information

 
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