A Concise and Efficient Approach to 2,6-Disubstituted 4-Fluoro­pyrimidines from α-CF₃ Aryl Ketones

Abstract

Herein, a concise and efficient protocol to synthesize a series of 2,6-disubstituted 4-fluoropyrimidines as universal and useful building blocks in medicinal chemistry is reported. From readily accessible α-CF₃ aryl ketones and different amidine hydrochlorides, this method provides a very practical approach to this kind of compounds under mild conditions with good to excellent yields.

Key words

fluoropyrimidine - α-CF₃ aryl ketone - metal-free - mild conditions

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