Synlett 2019; 30(19): 2153-2156
DOI: 10.1055/s-0039-1690217
letter
© Georg Thieme Verlag Stuttgart · New York

Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling

Authors


Financial support for this work was provided by the EPSRC, BBSRC, MRC, Wellcome Trust, ERC (FP7/2007–2013; 279337/DOS and Marie Curie Fellowship IEF-2013-627253), and by the Japan Science and Technology Agency (JST; ‘Global Science Campus’).
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Publication History

Received: 06 September 2019

Accepted after revision: 07 October 2019

Publication Date:
23 October 2019 (online)


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Abstract

N-Substituted dipropargylamines that are suitable as functionalized linkers for peptide stapling can be synthesized in one step under mild conditions from commercially available starting materials (41% to quantitative yield).

Supporting Information