Synthesis 2020; 52(12): 1779-1794
DOI: 10.1055/s-0039-1690088
paper
© Georg Thieme Verlag Stuttgart · New York

Environmentally Friendly Nafion-Mediated Friedländer Quinoline Synthesis under Microwave Irradiation: Application to One-Pot Synthesis of Substituted Quinolinyl Chalcones

Chieh-Kai Chan
,
Chien-Yu Lai
,
Cheng-Chung Wang
The authors thank Academia Sinica (AS-SUMMIT-108) and Ministry of Science and Technology, Taiwan (MOST 108-3114-Y-001-002 and MOST 108-2113-M-001-019-) for financial support.
Further Information

Publication History

Received: 06 February 2020

Accepted after revision: 25 February 2020

Publication Date:
19 March 2020 (online)


Abstract

An efficient and eco-friendly synthetic route for Friedländer quinoline synthesis of polysubstituted quinolines is described. This green chemical method starts from various 2-aminobenzophenones and mono- or dicarbonyl synthons and uses reusable Nafion NR50 material as a solid catalyst in ethanol under microwave irradiation. The protocol has a high generality of functional groups and provides the desired quinolines in good to excellent yields. Some structures were confirmed by single-crystal X-ray diffraction analysis.

Supporting Information

 
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