Synlett 2019; 30(07): 817-820
DOI: 10.1055/s-0037-1612256
letter
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Acridones by Palladium-Catalyzed Buchwald–Hartwig Amination

Authors

  • Julia Janke

    a   Institute of Chemistry, University Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Email: peter.langer@uni-rostock.de
  • Alexander Villinger

    a   Institute of Chemistry, University Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Email: peter.langer@uni-rostock.de
  • Peter Ehlers

    a   Institute of Chemistry, University Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Email: peter.langer@uni-rostock.de
    b   Leibniz-Institut für Katalyse e.V. an der Universität Rostock, A.-Einstein-Str. 29a, 18059 Rostock, Germany
  • Peter Langer*

    a   Institute of Chemistry, University Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany   Email: peter.langer@uni-rostock.de
    b   Leibniz-Institut für Katalyse e.V. an der Universität Rostock, A.-Einstein-Str. 29a, 18059 Rostock, Germany
Further Information

Publication History

Received: 06 December 2018

Accepted after revision: 03 February 2019

Publication Date:
25 March 2019 (online)


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Abstract

The Buchwald–Hartwig amination allows an efficient and convenient synthesis of biologically and pharmaceutically important acridones by formation of a six-membered ring. With the described method, a number of derivatives have been synthesized in up to 95% yield by using a variety of anilines as well as benzylic and aliphatic amines.

Supporting Information