A one-pot transformation of α,β-unsaturated trifluoromethyl ketones with 2-(phenylsulfinyl)acetamide
to give trifluoromethylated 2-pyridones is realized. The reaction proceeds under mild
conditions and involves multiple steps in an expeditious and controlled sequence to
provide efficient access to a broad range of trifluoromethylated 2-pyridones in moderate
to high yields. Moreover, further synthetic manipulations permit the routine synthesis
of a diverse array of trifluoromethylated pyridines with good efficiency.
Key words
trifluoromethyl group - pyridones - trifluoromethylpyridines - one-pot synthesis -
multistep reaction