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Synthesis 2019; 51(08): 1803-1808
DOI: 10.1055/s-0037-1611946
DOI: 10.1055/s-0037-1611946
paper
Copper-Catalyzed Decarboxylative N-Arylation of Indole-2-carboxylic Acids
We are grateful to the National Natural Science Foundation of China (Grant No. 21172142).Further Information
Publication History
Received: 05 September 2018
Accepted after revision: 17 November 2018
Publication Date:
10 January 2019 (online)
Abstract
A novel decarboxylative N-arylation of indole-2-carboxylic acids with aryl halides is developed. The reaction proceeds efficiently in the presence of Cu2O as the catalyst to give the corresponding N-aryl indoles in high yields. This synthetic method shows good functional group tolerance and offers an alternative route to construct N-aryl indoles.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1611946.
- Supporting Information
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For reviews, see:
For selected examples, see:
An example of copper(II)-catalyzed coupling of indole-2-carboxylic acid with bromobenzene giving 1-phenyl-indole-2-carboxylic acid has been reported, see: