Synlett 2019; 30(13): 1561-1564
DOI: 10.1055/s-0037-1611868
letter
© Georg Thieme Verlag Stuttgart · New York

Chelation-Based Homologation by Reaction of Organometallic Reagents with O-Alkyl S-Pyridin-2-yl Thiocarbonates: Synthesis of Esters from Grignard Reagents

Authors

  • Shun Usami

  • Tomoyuki Suzuki

  • Koudai Mano

  • Kosaku Tanaka III

  • Yoshimitsu Hashimoto

  • Nobuyoshi Morita

  • Osamu Tamura


This work was supported by JSPSKAKENHI Grant Number 17K0821 (O.T.).
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Publikationsverlauf

Received: 20. April 2019

Accepted after revision: 03. Juni 2019

Publikationsdatum:
27. Juni 2019 (online)


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This paper is dedicated to the memory of Professor Teruaki Mukaiyama, a prominent scientist who made major contributions to the field.

Abstract

The one-carbon homologative esterification of Grignard reagents with O-alkyl S-pyridin-2-yl thiocarbonates has been explored. This one-step synthesis of esters from Grignard reagents is the first case to involve chelation-stabilized intermediates.

Supporting Information