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Synthesis 2019; 51(10): 2149-2156
DOI: 10.1055/s-0037-1610693
DOI: 10.1055/s-0037-1610693
paper
Efficient Synthesis of 4,7-Dihydro-1H-oxepino[2,3-c]pyrazoles by Potassium Carbonate Promoted [4+3] Annulation of Crotonate-Derived Sulfur Ylides with Benzylidenepyrazolones
We thank the National Key Research and Development Program of China (2016YFD0201200), Tianjin Agricultural and Rural Work Committee (2016D01A016), and the State Key Laboratory of Elemento-Organic Chemistry in Nankai University for financial support.
Further Information
Publication History
Received: 28 October 2018
Accepted after revision: 16 January 2019
Publication Date:
19 February 2019 (online)
Dedicated in celebration of the 100th anniversary of Nankai University
Abstract
The [4+3] annulation reaction of crotonate-derived sulfur ylides with benzylidenepyrazolones using K2CO3 as the base is reported. The ready availability of starting materials and the simple cyclization procedure make this approach suitable for the preparation of a diverse array of 4,7-dihydro-1H-oxepino[2,3-c]pyrazoles in good to excellent yields.
Key words
4,7-dihydro-1H-oxepino[2,3-c]pyrazoles - [4+3] annulation reaction - crotonate-derived sulfur ylides - benzylidenepyrazolones - reaction mechanismSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0037-1610693.
- Supporting Information
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