Regioselective Addition of Quinoline Derivatives to Carbonyl Compounds via Palladium-Catalyzed Umpolung with Diethylzinc

Abstract

An efficient method for the C-4-selective addition of quinoline derivatives to carbonyl compounds is described. The combination of 2-ethoxy-1-ethoxycarbonyl-1,2-dihydroquinolines (EEDQs) with a palladium catalyst and diethylzinc generates nucleophilic allyl species which undergo addition to various aldehydes and ketones. C-4-Substituted quinoline derivatives are obtained in high to excellent yields with moderate diastereoselectivities.

Key words

palladium catalysis - diethylzinc - Umpolung - dihydroquinoline - regioselectivity

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