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CC BY ND NC 4.0 · Synlett 2019; 30(04): 483-487
DOI: 10.1055/s-0037-1610384
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Catalytic Enantioselective Synthesis of 4-Amino-1,2,3,4-tetrahydropyridine Derivatives from Intramolecular Nucleophilic Addition Reaction of Tertiary Enamides

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We thank the National Natural Science Foundation of China (No. 21320102002, 91427301) for financial support.
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Publication History

Received: 30 September 2018

Accepted after revision: 22 October 2018

Publication Date:
15 November 2018 (online)


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Published as part of the 30 Years SYNLETT – Pearl Anniversary Issue

Abstract

A general and efficient method for the synthesis of highly enantiopure 4-amino-1,2,3,4-tetradydropyridine derivatives based on chiral phosphoric acid catalyzed intramolecular nucleophilic addition of tertiary enamides to imines has been developed. We have also demonstrated a substrate engineering strategy to significantly improve the enantioselectivity of asymmetric catalysis

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