Copper(I)-Catalyzed Thiolation of C–H Bonds for the Synthesis of Sulfenyl Pyrroles and Indoles

Abstract

A novel and convenient copper(I)-catalyzed thiolation of C–H bonds of pyrroles and indoles is developed for the synthesis of sulfenyl pyrroles and indoles. Dual C–H thiolation reactions are observed for pyrroles. A wide range of pyrroles and indoles undergo the C–H thiolation smoothly with various disulfides and diselenides to generate the corresponding heteroaryl thioethers in moderate to excellent yields.

Key words

copper(I) iodide - ligands - thiolation - pyrroles - indoles

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