Synthesis 2018; 50(14): 2753-2760
DOI: 10.1055/s-0037-1610146
paper
© Georg Thieme Verlag Stuttgart · New York

Synthesis and Antiproliferative Properties of Bifunctional Allocolchicine Derivatives

Iuliia A. Gracheva
a  Department of Organic Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation   Email: afnn@rambler.ru
,
Elena V. Svirshchevskaya
b  Laboratory of Cell Interactions, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, 16/10 Miklukho-Maklaya Street, 117997 Moscow, Russian Federation
,
Vladimir I. Faerman
a  Department of Organic Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation   Email: afnn@rambler.ru
,
Irina P. Beletskaya
c  Department of Chemistry, M. V. Lomonosov Moscow State University, 1-3 Leninskiye Gory, 119992 Moscow, Russian Federation
,
Alexey Yu. Fedorov*
a  Department of Organic Chemistry, N.I. Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, 603950 Nizhny Novgorod, Russian Federation   Email: afnn@rambler.ru
› Author Affiliations
This work was supported by the Russian Science Foundation (project 16-13-10248).
Further Information

Publication History

Received: 21 March 2018

Accepted after revision: 18 April 2018

Publication Date:
28 May 2018 (online)


Abstract

Based on the natural antimitotic agent colchifoline as a lead structure, a series of novel bifunctional allocolchicine congeners were synthesized from commercial colchicine. The new derivatives maintain good cytotoxicity against T3M4, MiaPaCa-2, and PANC-1 cell lines. The presence of functional groups simplifies further modifications of the prepared structures and the design of novel colchicine-derived antitumor compounds with desired pharmacological properties.

Supporting Information

 
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