Synthesis 2018; 50(17): 3513-3519
DOI: 10.1055/s-0037-1610071
paper
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed C–N Bond Formation via C–H Functionalization: Facile Synthesis of Multisubstituted Imidazo[1,2-a]pyridines from N-(2-Pyridinyl)enaminones

Sandro Cacchi
a  Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Email: antonia.iazzetti@uniroma1.it
,
Alessia Ciogli
a  Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Email: antonia.iazzetti@uniroma1.it
,
Nicola Demitri
b  Elettra-Sincrotrone Trieste, S.S. 14 Km 163.5 in Area Science Park, 34149 Basovizza, Trieste, Italy
,
Giancarlo Fabrizi
a  Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Email: antonia.iazzetti@uniroma1.it
,
Francesca Ghirga
c  Center for Life Nano Science@Sapienza, Istituto Italiano di Tecnologia, Viale Regina Elena 291, 00161 Rome, Italy
,
Antonella Goggiamani
a  Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Email: antonia.iazzetti@uniroma1.it
,
Antonia Iazzetti*
a  Dipartimento di Chimica e Tecnologie del Farmaco, Sapienza, Università di Roma, P.le A. Moro 5, 00185 Rome, Italy   Email: antonia.iazzetti@uniroma1.it
,
Doriano Lamba
d  Istituto di Cristallografia–CNR, S.S. 14 Km 163.5 in Area Science Park, 34149 Basovizza, Trieste, Italy
› Author Affiliations
Further Information

Publication History

Received: 01 March 2018

Accepted after revision: 03 May 2018

Publication Date:
28 June 2018 (eFirst)

Abstract

An efficient, new copper-catalyzed approach to the construction of the multisubstituted imidazo[1,2-a]pyridine skeleton from N-(2-pyridinyl)enaminones has been developed.

Supporting Information

 
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