Abstract
Objective The objective of this study was to perform a systematic review of all studies that
report neurodevelopmental outcomes at 12 months' corrected age or later for preterm
infants (< 32 weeks) who are diagnosed with lenticulostriate vasculopathy (LSV) on
cranial ultrasound.
Study Design This is a systematic review.
Results We identified 501 unique publications of which 3 met all prespecified eligibility
criteria. Neurodevelopmental outcome data were available for 44 preterm infants with
LSV. There were mixed results from the studies: the first reported impairments of
mental development; the second reported impairments of motor development only; and
finally, the third reported that three of three preterm infants with LSV had mild
or moderate developmental delay.
Conclusion The available results raise some concern for future impairments in preterm infants
with LSV, but they are conflicting and inconclusive. There is insufficient evidence
about the neurodevelopmental implications of LSV in preterm infants to inform counseling
of parents.
Keywords
lenticulostriate vasculopathy - preterm infants - cranial ultrasound - neurodevelopmental
outcomes
