Lenticulostriate Vasculopathy and Neurodevelopmental Outcomes in Preterm Infants: A Systematic Review

Abstract

Objective The objective of this study was to perform a systematic review of all studies that report neurodevelopmental outcomes at 12 months' corrected age or later for preterm infants (< 32 weeks) who are diagnosed with lenticulostriate vasculopathy (LSV) on cranial ultrasound.

Study Design This is a systematic review.

Results We identified 501 unique publications of which 3 met all prespecified eligibility criteria. Neurodevelopmental outcome data were available for 44 preterm infants with LSV. There were mixed results from the studies: the first reported impairments of mental development; the second reported impairments of motor development only; and finally, the third reported that three of three preterm infants with LSV had mild or moderate developmental delay.

Conclusion The available results raise some concern for future impairments in preterm infants with LSV, but they are conflicting and inconclusive. There is insufficient evidence about the neurodevelopmental implications of LSV in preterm infants to inform counseling of parents.

Keywords

lenticulostriate vasculopathy - preterm infants - cranial ultrasound - neurodevelopmental outcomes

• References

• 1 Maayan-Metzger A, Leibovitch L, Schushan-Eisen I, Soudack M, Strauss T. Risk factors and associated diseases among preterm infants with isolated lenticulostriate vasculopathy. J Perinatol 2016; 36 (09) 775-778
• 2 Sisman J, Logan JW, Westra SJ, Allred EN, Leviton A. Lenticulostriate vasculopathy in extremely low gestational age newborns: inter-rater variability of cranial ultrasound readings, antecedents and postnatal characteristics. J Pediatr Neurol 2014; 12 (04) 183-193
• 3 Sisman J, Rosenfeld CR. Lenticulostriate vasculopathy in neonates: is it a marker of cerebral insult? Critical review of the literature. Early Hum Dev 2015; 91 (07) 423-426
• 4 Teele RL, Hernanz-Schulman M, Sotrel A. Echogenic vasculature in the basal ganglia of neonates: a sonographic sign of vasculopathy. Radiology 1988; 169 (02) 423-427
• 5 Grant EG, Williams AL, Schellinger D, Slovis TL. Intracranial calcification in the infant and neonate: evaluation by sonography and CT. Radiology 1985; 157 (01) 63-68
• 6 Hughes P, Weinberger E, Shaw DW. Linear areas of echogenicity in the thalami and basal ganglia of neonates: an expanded association. Work in progress. Radiology 1991; 179 (01) 103-105
• 7 Mittendorf R, Kuban K, Pryde PG, Gianopoulos JG, Yousefzadeh D. Antenatal risk factors associated with the development of lenticulostriate vasculopathy (LSV) in neonates. J Perinatol 2005; 25 (02) 101-107
• 8 Makhoul IR, Eisenstein I, Sujov P. , et al. Neonatal lenticulostriate vasculopathy: further characterisation. Arch Dis Child Fetal Neonatal Ed 2003; 88 (05) F410-F414
• 9 Chamnanvanakij S, Rogers CG, Luppino C, Broyles SR, Hickman J, Perlman JM. Linear hyperechogenicity within the basal ganglia and thalamus of preterm infants. Pediatr Neurol 2000; 23 (02) 129-133
• 10 Hong SY, Yang JJ, Li SY, Lee IC. Lenticulostriate vasculopathy in brain ultrasonography is associated with cytomegalovirus infection in newborns. Pediatr Neonatol 2015; 56 (06) 408-414
• 11 Bilavsky E, Schwarz M, Pardo J. , et al. Lenticulostriated vasculopathy is a high-risk marker for hearing loss in congenital cytomegalovirus infections. Acta Paediatr 2015; 104 (09) e388-e394
• 12 Amir J, Schwarz M, Levy I, Haimi-Cohen Y, Pardo J. Is lenticulostriated vasculopathy a sign of central nervous system insult in infants with congenital CMV infection?. Arch Dis Child 2011; 96 (09) 846-850
• 13 Nijman J, de Vries LS, Koopman-Esseboom C, Uiterwaal CS, van Loon AM, Verboon-Maciolek MA. Postnatally acquired cytomegalovirus infection in preterm infants: a prospective study on risk factors and cranial ultrasound findings. Arch Dis Child Fetal Neonatal Ed 2012; 97 (04) F259-F263
• 14 Ancora G, Lanari M, Lazzarotto T. , et al. Cranial ultrasound scanning and prediction of outcome in newborns with congenital cytomegalovirus infection. J Pediatr 2007; 150 (02) 157-161
• 15 de Jong EP, Lopriore E, Vossen AC. , et al. Is routine TORCH screening warranted in neonates with lenticulostriate vasculopathy?. Neonatology 2010; 97 (03) 274-278
• 16 Leijser LM, Vos N, Walther FJ, van Wezel-Meijler G. Brain ultrasound findings in neonates treated with intrauterine transfusion for fetal anaemia. Early Hum Dev 2012; 88 (09) 717-724
• 17 Kandasamy Y, Alcock G, Koh TH. Lenticulostriate vasculopathy in twin-to-twin transfusion syndrome. J Perinatol 2006; 26 (12) 780-782
• 18 Breysem L, Naulaers G, Deprest J. , et al. Postnatal cranial ultrasonographic findings in feto-fetal transfusion syndrome. Eur Radiol 2002; 12 (12) 2926-2932
• 19 El Ayoubi M, de Bethmann O, Monset-Couchard M. Lenticulostriate echogenic vessels: clinical and sonographic study of 70 neonatal cases. Pediatr Radiol 2003; 33 (10) 697-703
• 20 Soghier LM, Vega M, Aref K. , et al. Diffuse basal ganglia or thalamus hyperechogenicity in preterm infants. J Perinatol 2006; 26 (04) 230-236
• 21 Leijser LM, Steggerda SJ, de Bruïne FT. , et al. Lenticulostriate vasculopathy in very preterm infants. Arch Dis Child Fetal Neonatal Ed 2010; 95 (01) F42-F46
• 22 Shin HJ, Kim MJ, Lee HS, Namgung R, Park KI, Lee MJ. Imaging patterns of sonographic lenticulostriate vasculopathy and correlation with clinical and neurodevelopmental outcome. J Clin Ultrasound 2015; 43 (06) 367-374
• 23 Hemachandra AH, Oravec D, Collin M, Tafari N, Mhanna MJ. Early and late postnatal identification of isolated lenticulostriate vasculopathy in preterm infants: associated findings. J Perinatol 2003; 23 (01) 20-23