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Synlett 2018; 29(07): 969-973
DOI: 10.1055/s-0036-1591904
letter
© Georg Thieme Verlag Stuttgart · New York

Palladium-Catalyzed Oxidation of Indoles to Isatins by tert-Butyl Hydroperoxide

Junfei Luo*
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, P. R. of China   eMail: luojunfei@nbu.edu.cn
,
Shanshan Gao
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, P. R. of China   eMail: luojunfei@nbu.edu.cn
,
Yaorui Ma
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, P. R. of China   eMail: luojunfei@nbu.edu.cn
,
Guoping Ge
School of Materials Science and Chemical Engineering, Ningbo University, Ningbo 315211, P. R. of China   eMail: luojunfei@nbu.edu.cn
› InstitutsangabenThis research is sponsored by the research funds of Ningbo University (No. ZX2016000748) and by the K. C. Wong Magna Fund of Ningbo University.
Weitere Informationen

Publikationsverlauf

Received: 30. November 2017

Accepted after revision: 02. Januar 2018

Publikationsdatum:
31. Januar 2018 (online)

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Abstract

The combination of a Pd catalyst and tert-butyl hydro­peroxide (TBHP) is a powerful catalytic system for many types of oxidative transformations. Here, we report that a Pd/TBHP system facilitates the oxidation of indoles with a range of functionalities to give the corresponding isatin derivatives in good yields.

Key words

palladium catalysts - butyl hydroperoxide - oxidation - ­indoles - isatins

Supporting Information

    Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591904.
  • Supporting Information
 

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