Synlett 2018; 29(03): 257-265
DOI: 10.1055/s-0036-1591749
synpacts
© Georg Thieme Verlag Stuttgart · New York

Electrocatalytic Difunctionalization of Olefins as a General Approach to the Synthesis of Vicinal Diamines

Joseph B. Parry
a   Department of Chemistry and Chemical Biology, Cornell University, 259 East Avenue, Ithaca, NY 14853, USA
,
Niankai Fu
a   Department of Chemistry and Chemical Biology, Cornell University, 259 East Avenue, Ithaca, NY 14853, USA
,
Song Lin*
a   Department of Chemistry and Chemical Biology, Cornell University, 259 East Avenue, Ithaca, NY 14853, USA
b   Atkinson Center for a Sustainable Future, Cornell University, Ithaca, NY 14853, USA   Email: songlin@cornell.edu
› Author Affiliations
Financial support was provided by Cornell University and the Atkinson Center for a Sustainable Future.
Further Information

Publication History

Received: 18 November 2017

Accepted after revision: 10 December 2017

Publication Date:
15 January 2018 (online)


Dedicated to Professor Bruce Ganem on the occasion of his 70th birthday

Abstract

Vicinal diamines are highly prevalent structural motifs in therapeutic agents, bioactive natural products, and molecular catalysts. However, there are currently few unified methodological approaches for making these pertinent synthetic building blocks. This Synpacts article provides an overview of selected landmark developments in the area of olefin diamination. In particular, we highlight our recent contribution on the electrocatalytic diazidation of olefins as a general, selective, and sustainable method for the synthesis of vicinal diamines.

1 Introduction

2 Background: Intermolecular Diamination of Olefins

3 Background: Intermolecular Diazidation of Olefins

4 Electrocatalytic Diazidation of Olefins

 
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