Expedient Synthesis of Long-Chain ω-Substituted Fatty Acids and Esters from Cyclic Ketones Using Iodine and Hydrogen Peroxide

Abstract

A simple and convenient synthesis of ω-iodoaliphatic carboxylic acids and esters by the reaction of cyclic ketones with iodine and hydrogen peroxide in the presence of catalytic CuCl has been developed. ω-Iodoaliphatic carboxylic esters were further used for the efficient preparation of di(2-pyridylmethylamino)alkanoic acids in excellent yields.

Key words

cyclic ketones - ω-iodoaliphatic carboxylic acids - ω-iodo­aliphatic carboxylic esters - ligands - di-(2-picolyl)amine - di-(2-pyridylmethylamino)alkanoic acids - chelating reagents

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