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Synthesis 2018; 50(19): 3931-3935
DOI: 10.1055/s-0036-1591587
DOI: 10.1055/s-0036-1591587
paper
A Simple Route to Benzo[b]xanthene-6,11,12-triones: Synthesis of Bikaverin
Authors
Weitere Informationen
Publikationsverlauf
Received: 23. April 2018
Accepted after revision: 24. April 2018
Publikationsdatum:
09. Juli 2018 (online)
Abstract
A three-step procedure for the synthesis of 1H-benzo[b]xanthene-6,11,12-trione derivatives is described. The procedure involves the halogenation of 12-(3-hydroxy-1,4-naphthoquinon-2-yl)-6H-benzo[b]xanthene-6,11-(12H)-diones, followed by treatment with water under aeration. In this manner, bikaverin, a cytotoxic metabolite isolated from several species of the fungal genera Gibberella, Fusarium, and Mycogone, was synthesised.
Key words
1H-benzo[b]xanthene-6,11,12-triones - bikaverin - 7,10-dihydroxy-3,8-dimethoxy-1-methyl-1H-benzo[b]xanthene-6,11,12-trione - Gibberella - Fusarium - MycogoneSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591587.
- Supporting Information (PDF)
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