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Synthesis 2018; 50(09): 1921-1925
DOI: 10.1055/s-0036-1591538
DOI: 10.1055/s-0036-1591538
paper
A Practical and Efficient Synthesis of (±)-Anatabine
Autoren
This work was supported by the University of Camerino and Indena S.p.a.
Weitere Informationen
Publikationsverlauf
Received: 07. Dezember 2017
Accepted after revision: 11. Dezember 2017
Publikationsdatum:
12. Februar 2018 (online)
Abstract
A new efficient synthesis of racemic anatabine is reported. The title target was obtained in an excellent overall yield of 70%, by a five-step synthesis, using cheap reagents and mild reaction conditions.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1591538.
- Supporting Information (PDF) (opens in new window)
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- 13b The N-Boc anatabine 5 can be directly converted into 6 in lower yield (72%) and longer reaction time (8 h) working at 0 °C in a 0.06 M TFA/CH2Cl2 (1:1) solution.