Synthesis 2018; 50(03): 548-554
DOI: 10.1055/s-0036-1591497
paper
© Georg Thieme Verlag Stuttgart · New York

Friedel–Crafts Alkylation of Aromatics by TiCl4-Promoted Ring Cleavage of 3-Arylcyclobutanones

Mayu Kanie
Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan   Email: jimatsuo@p.kanazawa-u.ac.jp
,
Tomoyuki Yoshimura
Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan   Email: jimatsuo@p.kanazawa-u.ac.jp
,
Jun-ichi Matsuo*
Division of Pharmaceutical Sciences, Graduate School of Medical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan   Email: jimatsuo@p.kanazawa-u.ac.jp
› Author Affiliations
This work was supported by JSPS KAKENHI Grant Number 15K07855.
Further Information

Publication History

Received: 07 August 2017

Accepted after revision: 27 September 2017

Publication Date:
06 November 2017 (online)


Dedicated to Professor Teruaki Mukaiyama in celebration of his 90th birthday

Abstract

Ring cleavage of 3-arylcyclobutanones and successive Friedel–Crafts alkylation of methoxy- or alkyl-substituted benzene derivatives proceeded to give 3,3-diarylbutan-2-ones by activation with titanium tetrachloride.

Supporting Information

 
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