This work is dedicated to Professor Jin Baek Kim on the occasion of his honorable
retirement
Abstract
The isolation of flueggenines A and B by Yue and co-workers in 2006 has triggered
a burst of isolation reports of dimeric and oligomeric securinega alkaloid natural
products. The compelling molecular structures of these compounds with various modes
of connection between monomeric securinega units have posed intriguing challenges
to the synthetic organic community. Herein, we have categorized high-order securinega
alkaloids based on their biosynthetic mode of dimerization or oligomerization. We
then have compiled all reported syntheses of dimeric securinega alkaloids based on
our classification.
1 Introduction
2 Categorization of High-Order Securinega Alkaloid Natural Products
3 Syntheses of Type I Dimeric Securinega Alkaloids
4 Syntheses of Type II Dimeric Securinega Alkaloids
5 Synthesis of Type III Dimeric Securinega Alkaloid
6 Conclusion
Key words
securinega alkaloids - conjugate addition - cycloaddition - Rauhut–Currier reaction
- total synthesis
