Recent Advances in Ring-Opening Polymerization of O-CarboxyanhydridesThis work was supported by start-up funding from Virginia Polytechnic Institute and State University. Q.F. acknowledges support from National Natural Science Foundation of China (21504047), Natural Science Foundation of Jiangsu Province (BK20150834), Nanjing University of Posts and Telecommunications Scientific Foundation NUPTSF (NY214179).
Received: 06 May 2017
Accepted after revision: 21 June 2017
03 August 2017 (eFirst)
Poly(α-hydroxy acids) are important biodegradable polymers with wide applications. Recently O-carboxyanhydrides (OCAs) have emerged as promising monomer equivalents of lactides to synthesize poly(α-hydroxy acids). We will highlight recent advances in controlled ring-opening polymerization of OCAs catalyzed by organocatalysts, enzymes, or organometallic complexes.
2 Organocatalysts for O-Carboxyanhydride Polymerization
2.1 Synthesis of O-Carboxyanhydride Monomers
2.2 Ring-Opening Polymerization of O-Carboxyanhydrides Catalyzed by 4-Dimethylaminopyridine
2.3 Epimerization in the Ring-Opening Polymerization of O-Carboxyanhydrides Catalyzed by the Pyridine Base
2.4 N-Heterocyclic Carbenes for Ring-Opening Polymerization of O-Carboxyanhydrides
3 Enzymes for O-Carboxyanhydride Polymerization
4 Organometallic Catalysts for O-Carboxyanhydride Polymerization
4.1 Early Efforts
4.2 Ring-Opening Polymerization Catalyzed by Zn Complexes
4.3 Photoredox Ring-Opening Polymerization Catalyzed by Zn/Ni Complexes
5 Conclusion and Perspective