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CC BY 4.0 · Synlett 2017; 28(20): 2855-2858
DOI: 10.1055/s-0036-1589096
DOI: 10.1055/s-0036-1589096
letter
Rapid Continuous Ruthenium-Catalysed Transfer Hydrogenation of Aromatic Nitriles to Primary Amines
This work was supported by Eli Lilly & Co. through the Lilly Research Award Program (LRAP). This work has also been funded by the EPSRC (SVL, grants EP/K009494/1, EP/M004120/1 and EP/K039520/1).Further Information
Publication History
Received: 23 June 2017
Accepted after revision: 18 July 2017
Publication Date:
21 August 2017 (online)
Dedicated to our friend Vic Snieckus on the occasion of his 80th birthday
Abstract
A continuous flow method for the selective reduction of aromatic nitriles to the corresponding amine is reported. The method is based on a ruthenium-catalysed transfer-hydrogenation process, requires no additives, and uses isopropanol as both solvent and reducing agent. The process utilizes 1 mol% of the commercially available [Ru(p-cymene)Cl2]2, with a residence time of ca. 9 min, and a throughput of 50 mmol/h. The method was successfully applied to a range of aromatic nitriles providing the corresponding primary amines in good yields.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1589096. Additional data is available from the University of Cambridge Data Repository website: https://doi.org/10.17863/CAM.10921.
- Supporting Information
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